Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840

Abstract

In our survey for antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated antibiotics was identified as phoslactomycin E based on LC-MS and NMR spectral data. In a preliminary assay using the membrane fractions of A. fumigatus, phoslactomycin E was found to inhibit the activity of 1,3-β glucan synthase.

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Correspondence to Yoshinosuke Usuki or Ken-Ichi Fujita.

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Mizuhara, N., Usuki, Y., Ogita, M. et al. Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840. J Antibiot 60, 762–765 (2007). https://doi.org/10.1038/ja.2007.101

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Keywords

  • antifungal activity
  • phoslactomycin E
  • Aspergillus fumigatus
  • hyphal morphological abnormalities
  • 1,3-β glucan synthase

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