Abstract
Biosynthetic studies of the antifungal agent, FR-900848, were undertaken by feeding experiments with D-[U-13C6]glucose, L-[4-13C]aspartate, [5,5-2H2]dihydrouridine and [5,5-2H2]dihydrouracil. The 5″-amino-5″-deoxy-5′,6′-dihydrouridine moiety was derived from ribose and aspartate. Based on the feeding experiments, a detailed biosynthetic pathway producing the aminodeoxydihydrouridine moiety of FR-900848 was proposed.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Watanabe, H., Tokiwano, T. & Oikawa, H. Biosynthetic Study of FR-900848: Origin of the Aminodeoxynucleoside Part. J Antibiot 59, 607–610 (2006). https://doi.org/10.1038/ja.2006.82
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ja.2006.82