A New Antifungal Macrolide, Eushearilide, Isolated from Eupenicillium shearii

Article metrics

Abstract

In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.

References

  1. 1

    Georgopapadakou NH, Walsh TJ . Antifungal agents: chemotherapeutic targets and immunologic strategies. J Antimicrob Agents Chemother 40: 279–291 ( 1996)

  2. 2

    Hosoe T, Fukushima K, Itabashi T, Nozawa K, Takizawa K, Okada K, Takaki GMC, Kawai K . A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM52672. J Antibiot 57: 573–578 ( 2004)

  3. 3

    Komai S, Hosoe T, Nozawa K, Okada K, Takaki GMC, Fukushima K, Miyaji M, Horie Y, Kawai K . Antifungal activity of pyranone and furanone derivatives, isolated from Aspergillus sp. IFM51759, against Aspergillus fumigatus. Mycotoxins 53: 11–18 ( 2003)

  4. 4

    Inoue S, Sezaki M . Current antifungal antibiotics. Yukigoseikagakukyoukaishi 51: 327–349 ( 1993)

Download references

Author information

Correspondence to Tomoo Hosoe.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hosoe, T., Fukushima, K., Takizawa, K. et al. A New Antifungal Macrolide, Eushearilide, Isolated from Eupenicillium shearii. J Antibiot 59, 597–600 (2006) doi:10.1038/ja.2006.80

Download citation

Keywords

  • Eupenicillium shearii
  • eushearilide
  • macrolide
  • antifungal activity

Further reading