Abstract
Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2′-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2′-demethoxy-2′propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
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Oda, T. Effects of 2′-Demethoxy-2′-propoxygriseofulvin on Microtubule Distribution in Chinese Hamster V79 Cells. J Antibiot 59, 114–116 (2006). https://doi.org/10.1038/ja.2006.17
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DOI: https://doi.org/10.1038/ja.2006.17