Abstract
Three sterol-type compounds (compounds 4, 5 and 6) were isolated from culture broth of pathogenic Nocardia otitidiscaviarum IFM 0988 and Amycolatopsis sp. IFM 0703 strains which were isolated from Japanese patients. The structures of the compounds were determined by NMR and mass spectrometric analyses. The structural studies indicated that compound 4 is a biotransformation product from cholic acid derivative in a nutrient culture medium constituent by a reductase-type enzyme, and the remaining two compounds 5 and 6 are also biotransformation ones by oxidase-type enzymes.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mukai, A., Yazawa, K., Mikami, Y. et al. Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp. Strains. J Antibiot 58, 356–360 (2005). https://doi.org/10.1038/ja.2005.46
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ja.2005.46