Abstract
A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7 µM.
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Rochfort, S., Ford, J., Ovenden, S. et al. A Novel Aspochalasin with HIV-1 Integrase Inhibitory Activity from Aspergillus flavipes. J Antibiot 58, 279–283 (2005). https://doi.org/10.1038/ja.2005.34
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DOI: https://doi.org/10.1038/ja.2005.34
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