Original Article | Published:

Clinical Studies and Practice

Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype

International Journal of Obesity volume 39, pages 13651370 (2015) | Download Citation

Abstract

Background:

A proportion of obese subjects appear metabolically healthy (MHO) but little is known about the natural history of MHO and factors predicting its future conversion to metabolically unhealthy obese (MUO).

Objectives:

The aim was to determine prospectively the frequency of conversion of MHO to MUO and the clinical variables that independently predicted this conversion, with a particular focus on the role of body composition.

Methods:

We identified 85 Japanese Americans with MHO (56 men, 29 women), aged 34–73 years (mean age 49.8 years) who were followed at 2.5, 5 and 10 years after enrollment with measurements of metabolic characteristics, lifestyle and abdominal and thigh fat areas measured by computed tomography. Obesity was defined using the Asian body mass index criterion of 25 kg m−2. Metabolically healthy was defined as the presence of 2 of 5 metabolic syndrome components proposed by the National Cholesterol Education Program Adult Treatment Panel III, while metabolically unhealthy was defined as 3 components.

Results:

Over 10 years of follow-up, 55 MHO individuals (64.7%) converted to MUO. Statistically significant univariate predictors of conversion included dyslipidemia, greater insulin resistance and greater visceral abdominal (VAT) and subcutaneous abdominal fat area (SAT). In multivariate analysis, VAT (odds ratio per 1-s.d. increment (95% confidence interval) 2.04 (1.11–3.72), P=0.021), high-density lipoprotein (HDL) cholesterol (0.24 (0.11–0.53), P<0.001), fasting plasma insulin (2.45 (1.07–5.62), P=0.034) and female sex (5.37 (1.14–25.27), P=0.033) were significantly associated with future conversion to MUO. However, SAT was not an independent predictor for future conversion to MUO.

Conclusions:

In this population, MHO was a transient state, with nearly two-thirds developing MUO over 10 years, with higher conversion to MUO independently associated with VAT, female sex, higher fasting insulin level and lower baseline HDL cholesterol level.

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Acknowledgements

This work was supported by facilities and services provided by the Diabetes Research Center (DK-17047), Clinical Nutrition Research Unit (DK-35816), and the General Clinical Research Center (RR-00037) at the University of Washington. VA Puget Sound Health Care System provided support for Drs Boyko and Kahn’s involvement in this research. We are grateful to the King County Japanese American community for support and cooperation. Funding was through National Institutes of Health grants DK-31170, HL-49293 and DK-017047. The funding entities had no role in the conduct of this study or interpretation of its results.

Author information

Author notes

    • M J McNeely

    Deceased

Affiliations

  1. Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA

    • Y-C Hwang
    •  & E J Boyko
  2. Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea

    • Y-C Hwang
  3. Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City University, Osaka, Japan

    • T Hayashi
  4. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

    • W Y Fujimoto
    • , S E Kahn
    • , M J McNeely
    •  & E J Boyko
  5. Hospital and Specialty Medicine Service, VA Puget Sound Health Care System, Seattle, WA, USA

    • S E Kahn
  6. Department of Anthropology, University of Washington, Seattle, WA, USA

    • D L Leonetti

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to E J Boyko.

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DOI

https://doi.org/10.1038/ijo.2015.75

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