Review | Published:

Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis

International Journal of Obesity volume 39, pages 11971202 (2015) | Download Citation

Abstract

Background:

Psoriasis is a chronic inflammatory disease of the skin with joint manifestations. Greater psoriasis severity and lower response to treatment have been linked to obesity. However, the effect of weight reduction by non-pharmacologic intervention on disease severity is still questionable. This is a systematic review and meta-analysis of randomized controlled trials (RCTs) on the effect of dietary and lifestyle weight loss interventions on psoriasis severity.

Methods:

We comprehensively searched PubMed/MEDLINE, EMBASE and CENTRAL from their inception to August 2014. Inclusion criteria were RCTs that examined lifestyle intervention by diet or exercise in overweight or obese patients with psoriasis and measured the severity of psoriasis as an outcome compared with controls. Two authors independently assessed article quality and extracted the data.

Results:

Out of 12 full-text articles, 7 RCTs involving 878 participants met our inclusion criteria. Five of these RCTs were included in the meta-analysis, which was based on the random-effects model. There was a greater reduction in the Psoriasis Area Severity Index (PASI) score in patients receiving weight loss intervention than in controls, with a pooled mean difference of −2.49 (95% confidence interval (CI), −3.90 to −1.08; P=0.004). More participants in the intervention group than in the control group achieved a 75% reduction in the PASI score, with a pooled odds ratio of 2.92 (95% CI, 1.39–6.13; P=0.005).

Conclusion:

Nonpharmacologic, nonsurgical weight loss intervention is associated with reduction in the severity of psoriasis in overweight or obese patients. However, more RCTs with more participants are needed to provide better quality of evidence.

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Acknowledgements

The authors thank Matthew Roslund for his contribution to this review.

Author information

Author notes

    • S Upala
    •  & A Sanguankeo

    These authors contributed equally to this work.

Affiliations

  1. Department of Internal Medicine, Bassett Medical Center, Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA

    • S Upala
    •  & A Sanguankeo
  2. Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    • S Upala
    •  & A Sanguankeo

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to A Sanguankeo.

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DOI

https://doi.org/10.1038/ijo.2015.64

Supplementary Information accompanies this paper on International Journal of Obesity website (http://www.nature.com/ijo)

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