Only limited epidemiological evidence exists regarding the relationship between diabetic neuropathy and erectile dysfunction (ED) among Japanese patients with type 2 diabetes mellitus. To investigate the relationship between diabetic neuropathy and ED among Japanese patients with type 2 diabetes mellitus, a multicenter cross-sectional study was conducted in 287 male Japanese patients with type 2 diabetes mellitus, age (19–65 years). Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, decreased or disappeared Achilles tendon reflex and/or abnormal vibration perception. ED, moderate to severe ED, and severe ED were defined as present when a subject had a Sexual Health Inventory for Men score <22, <12 and <8, respectively. The prevalence values of diabetic neuropathy and severe ED were 47.0 and 39.0%, respectively. Diabetic neuropathy was independently positively associated with severe ED, but not ED and moderate ED: the adjusted odds ratio was 1.90 (95% confidence interval: 1.08–3.38). No relationships were found between diabetic retinopathy or diabetic nephropathy and ED. Diabetic neuropathy is positively associated with severe erectile dysfunction among Japanese type 2 diabetes mellitus patients aged <65 years.
Subscribe to Journal
Get full journal access for 1 year
only $32.38 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.
Bacon CG, Hu FB, Giovannucci E, Glasser DB, Mittleman MA, Rimm EB . Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002; 25: 1458–1463.
Malavige LS, Levy JC . Erectile dysfunction in diabetes mellitus. J Sex Med 2009; 6: 1232–1247.
Cho NH, Ahn CW, Park JY, Ahn TY, Lee HW, Park TS et al. Prevalence of erectile dysfunction in Korean men with type 2 diabetes mellitus. Diabet Med 2006; 23: 198–203.
Zheng H, Fan W, Li G, Tam T . Predictors for erectile dysfunction among diabetics. Diabetes Res Clin Pract 2006; 71: 313–319.
Siu SC, Lo SK, Wong KW, Ip KM, Wong YS . Prevalence of and risk factors for erectile dysfunction in Hong Kong diabetic patients. Diabet Med 2001; 18: 732–738.
Klein R, Klein BE, Lee KE, Moss SE, Cruickshanks KJ . Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care 1996; 19: 135–141.
Fedele D, Coscelli C, Santeusanio F, Bortolotti A, Chatenoud L, Colli E et al. Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici. Diabetes Care 1998; 21: 1973–1977.
Sasaki H, Yamasaki H, Ogawa K, Nanjo K, Kawamori R, Iwamoto Y et al. Prevalence and risk factors for erectile dysfunction in Japanese diabetics. Diabetes Res Clin Pract 2005; 70: 81–89.
Yamasaki H, Ogawa K, Sasaki H, Nakao T, Wakasaki H, Matsumoto E et al. Prevalence and risk factors of erectile dysfunction in Japanese men with type 2 diabetes. Diabetes Res Clin Pract 2004; 66: s173–s177.
Fukui M, Tanaka M, Okada H, Iwase H, Mineoka Y, Senmaru T et al. Five-item version of the international index of erectile function correlated with albuminuria and subclinical atherosclerosis in men with type 2 diabetes. J Atheroscler Thromb 2011; 18: 991–997.
Penson DF, Latini DM, Lubeck DP, Wallace KL, Henning JM, Lue TF . Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database. Diabetes Care 2003; 26: 1093–1099.
De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH et al. Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes Care 2002; 25: 284–291.
Vickers MA, Satyanarayana R . Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res 2002; 14: 466–471.
Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T . Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 2005; 28: 164–176.
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009; 53: 982–992.
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K et al. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Clin Exp Nephrol 2014; 18: 621–622.
Yasuda H, Sanada M, Kitada K, Terashima T, Kim H, Sakaue Y et al. Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy. Diabetes Res Clin Pract 2007; 77: S178–S183.
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319–326.
McCulloch DK, Campbell IW, Wu FC, Prescott RJ, Clarke BF . The prevalence of diabetic impotence. Diabetologia 1980; 18: 279–283.
García-Malpartida K, Mármol R, Jover A, Gómez-Martínez MJ, Solá-Izquierdo E, Victor VM et al. Relationship between erectile dysfunction and silent myocardial ischemia in type 2 diabetic patients with no known macrovascular complications. J Sex Med 2011; 8: 2606–2616.
Chuang YC, Chung MS, Wang PW, Lee WC, Chen CD, Chang HW et al. Albuminuria is an independent risk factor of erectile dysfunction in men with type 2 diabetes. J Sex Med 2012; 9: 1055–1064.
Hecht MJ, Neundörfer B, Kiesewetter F, Hilz MJ . Neuropathy is a major contributing factor to diabetic erectile dysfunction. Neurol Res 2001; 23: 651–654.
Sima AA, Sugimoto K . Experimental diabetic neuropathy: an update. Diabetologia 1999; 42: 773–788.
Yagihashi S, Yamagishi S, Wada R . Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms. Diabetes Res Clin Pract 2007; 77: S184–S189.
Fedele D, Bortolotti A, Coscelli C, Santeusanio F, Chatenoud L, Colli E et al. Erectile dysfunction in type 1 and type 2 diabetics in Italy. On behalf of Gruppo Italiano Studio Deficit Erettile nei Diabetici. Int J Epidemiol 2000; 29: 524–531.
Wessells H, Penson DF, Cleary P, Rutledge BN, Lachin JM, McVary KT et al. Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes. J Urol 2011; 185: 1828–1834.
Jin Y, Kanamori A, Ito S, Matoba K, Miyakawa N, Kaneshige H et al. Cross-sectional survey of diabetic neuropathy in Kanagawa and clinical significance of a touch test using tissue paper. J Diabetes Investig 2012; 3: 252–258.
This study was supported by JSPS KAKENHI Grants (217090583 and 23790697). We thank Eriko Kawamoto from Matsuyama City Hospital, Keiko Kikuchi from Ehime University and Eri Furukawa from Furukawa Clinic. JSPS KAKENHI Grants (217090583 and 23790697).
The authors declare no conflict of interest.
About this article
Cite this article
Furukawa, S., Sakai, T., Niiya, T. et al. Diabetic peripheral neuropathy and prevalence of erectile dysfunction in Japanese patients aged <65 years with type 2 diabetes mellitus: The Dogo Study. Int J Impot Res 29, 30–34 (2017). https://doi.org/10.1038/ijir.2016.40
Current Sexual Health Reports (2019)