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Early onset erectile dysfunction is usually not associated with abnormal cavernosal arterial Inflow

International Journal of Impotence Research volume 25, pages 217–220 (2013)Cite this article

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Abstract

Endothelial dysfunction, a marker for atherosclerosis and hence arterial disease, has recently been proffered as the main offender within the vascular system to predict not only the future onset of erectile dysfunction (ED) but also as the main cause of the ED. To glean more insight into whether arterial disease is indeed operative during the early onset of ED, we reviewed the duplex ultrasound scans of 23 men with ED who were younger than 50 years of age. Depending on the criteria used for abnormal arterial responses, it was determined in this cohort of young men that there was only a 4–13% incidence of abnormal arterial responses. These observations suggest that the penile arterial system does not appear to be primarily involved in the etiology of the majority cases of ED that occur in young men.

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References

  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.

    Article  CAS  Google Scholar 

  2. Melman A, Kaplan D . Redfield. Evaluation of the first 70 patients in the center for male sexual dysfunction of Beth Israel Medical Center. J Urol 1984; 131: 53–55.

    Article  CAS  Google Scholar 

  3. Lue TF, Tanagho EA . Physiology of erection and pharmacological management of erection. J Urol 1987; 137: 829–836.

    Article  CAS  Google Scholar 

  4. Ellis LR, Nellans RE, Kramer-Levien DJ, Knoepfler GS, Knoepfler P . Evaluation of the first 300 patients treated at an outpatient center for male sexual dysfunction. West J Med 1987; 147: 296–300.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Rajfer J, Rosciszewski A, Mehringer M . Prevalence of corporeal venous leakage in impotent men. J Urol 1988; 140: 69–71.

    Article  CAS  Google Scholar 

  6. Lue TF, Takamura T, Schmidt RA, Palubinskas AJ, Tanagho EA . Hemodynamics of erection in the monkey. J Urol 1983; 130: 1237–1241.

    Article  CAS  Google Scholar 

  7. Delcour C, Wespes E, Schulman CC, Struwen J . Investigation of the venous system in impotence of vascular origin. Urol Radiol 1984; 6: 190–193.

    Article  CAS  Google Scholar 

  8. Bookstein JJ . Cavernosal venocclusive insufficiency in male impotence: evaluation of degree and location. Radiology 1987; 164: 175–178.

    Article  CAS  Google Scholar 

  9. Vlachopoulos C, Rokkas K, Ioakeimidis N, Stefanadis C . Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. Eur Urol 2007; 52: 1590–1600.

    Article  CAS  Google Scholar 

  10. Meldrum DR, Gambone JC, Morris MA, Meldrum DAN, Esposito K, Ignarro LJ . The link between erectile and cardiovascular health: the canary and the coal mine. Am J Cardiol 2011; 108: 599–606.

    Article  Google Scholar 

  11. Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A et al. Erectile dysfunction, prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003; 44: 360–365.

    Article  Google Scholar 

  12. Solomon H, DeBusk RF, Jackson G . Erectile dysfunction: the need to be evaluated, the right to be treated. Am Heart J 2005; 150: 620–626.

    Article  Google Scholar 

  13. Chirulia E, D’Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG . Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol 2005; 46: 1503–1506.

    Article  Google Scholar 

  14. Stief CG, Bahren W, Gall H, Scherb W . Functional evaluation of penile hemodynamics. J Urol 1988; 139: 734–737.

    Article  CAS  Google Scholar 

  15. Lue TF, Mueller SC, Jow YR, Hwang TI-S . Functional evaluation of penile arteries with duplex ultrasound in vasodilator-induced erection. Urol Clin N Am 1989; 16: 799–807.

    CAS  Google Scholar 

  16. Solomon H, Man JW, Jackson G . Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251–254.

    Article  CAS  Google Scholar 

  17. Mersdorf A, Goldsmith PC, Diederichs W, Padula CA, Lue TF, Fishman IJ et al. Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J Urol 1991; 145: 749–758.

    Article  CAS  Google Scholar 

  18. Nehra A, Goldstein I, Pabby A, Nugent M, Huang YH, de las Morenas A et al. Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure. J Urol 1996; 156: 1320–1329.

    Article  CAS  Google Scholar 

  19. Muller SC, el-Damanhoury H, Ruth J, Lue TF . Hypertension and impotence. Eur Urol 1991; 19: 29–34.

    Article  CAS  Google Scholar 

  20. Aversa A, Mazzilli F, Rossi T, Delfino M, Isidori AM, Fabbri A . Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. Hum Reprod 2000; 15: 131–134.

    Article  CAS  Google Scholar 

  21. Mondaini N, Ponchietti R, Muir GH, Montorsi F, Di Loro F, Lombardi G et al. Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time. Int J Impot Res 2003; 15: 225–228.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA

    J Rajfer & J Valeriano

  2. Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA

    J Rajfer

  3. Department of Radiology, Harbor-UCLA Medical Center, Torrance, CA, USA

    R Sinow

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  1. J Rajfer
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  2. J Valeriano
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  3. R Sinow
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Correspondence to J Rajfer.

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Rajfer, J., Valeriano, J. & Sinow, R. Early onset erectile dysfunction is usually not associated with abnormal cavernosal arterial Inflow. Int J Impot Res 25, 217–220 (2013). https://doi.org/10.1038/ijir.2013.17

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  • DOI: https://doi.org/10.1038/ijir.2013.17

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