We investigated the effects of Antep pistachio on International Index of Erectile Function (IIEF) scores, penile color Doppler ultrasound (PCDU) parameters and serum lipid levels in patients with ED. A total of 17 married male patients with ED for at least 12 months were included in this prospective study. Patients were put on a 100 g pistachio nuts diet for 3 weeks. IIEF and PCDU were evaluated before and after the pistachio diet. In addition, plasma total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride were measured before and after dietary modifications from all subjects. Mean IIEF-15 score was 36±7.5 before the diet and 54.2±4.9 after the diet (P=0.001). Similarly, an increase in all five domains of IIEF was observed after the diet (P<0.05). Mean peak systolic velocity values before and after the pistachio diet were 35.5±15.2 and 43.3±12.4 cm s–1, respectively (P=0.018). After the pistachio diet, TC and LDL levels decreased significantly, whereas HDL level increased (P=0.008, 0.007 and 0.001, respectively). We demonstrated that a pistachio diet improved IIEF scores and PCDU parameters without any associated side effects in patients with ED. Furthermore, the lipid parameters showed statistically significant improvements after this diet.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Simonsen U, Garcia-Sacristan A, Prieto D . Penile arteries and erection. J Vasc Res 2002; 39: 283–303.
Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejeda I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R . Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfunction Erectil Masculina Study. J Urol 2001; 166: 569–574.
Michal V . Arterial disease as a cause of impotence. Clin Endocrinol Metab 1982; 11: 725–748.
Gentile C, Tesoriere L, Butera D, Fazzari M, Monastero M, Allegra M et al. Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components. J Agric Food Chem 2007; 55: 643–648.
Nyquist RC . Nuts nutrition and health benefits of daily use. Nutr Today 1997; 32: 157–163.
Sari I, Baltaci Y, Bagci C, Davutoglu V, Erel O, Celik H et al. Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition 2010; 26: 399–404.
Kloner RA . Erectile dysfunction and cardiovascular risk factors. Urol Clin North Am 2005; 32: 397–402.
Araujo AB, Hall SA, Ganz P, Chiu GR, Rosen RC, Kupelian V et al. Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol 2010; 55: 350–356.
Kris-Etherton PM, Zhao G, Binkoski AE, Coval SM, Etherton TD . The effects of nuts on coronary heart disease risk. Nutr Rev 2001; 59: 103–111.
Dreher ML, Maher CV, Kearney P . The traditional and emerging role of nuts in healthful diets. Nutr Rev 1996; 54: 241–245.
Sheridan MJ, Cooper JN, Erario M, Cheifetz CE . Pistachio nut consumption and serum lipid levels. J Am Coll Nutr 2007; 26: 141–148.
Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A . The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822–830.
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319–326.
Kocyigit A, Koylu AA, Keles H . Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutr Metab Cardiovasc Dis 2006; 16: 202–209.
Edwards K, Kwaw I, Matud J, Kurtz I . Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr 1999; 18: 229–232.
Wilkins CJ, Sriprasad S, Sidhu PS . Colour doppler ultrasound of the penis. Clin Radiol 2003; 58: 514–523.
Kurowski EM, Carroll KK . Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr 1994; 124: 364–370.
Slater TF . Free-radical mechanisms in tissue injury. Biochem J 1984; 222: 1–15.
Tokusoglu O, Unal MK, Yemis F . Determination of the phytoalexin resveratrol (3,5,4′-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem 2005; 53: 5003–5009.
Pasqualini L, Cortese C, Marchesi S, Siepi D, Pirro M, Vaudo G et al. Paraoxonase-1 activity modulates endothelial function in patients with peripheral arterial disease. Atherosclerosis 2005; 183: 349–354.
Ciftci H, Yeni E, Savas M, Verit A, Celik H . Paraoxonase activity in patients with erectile dysfunction. Int J Impot Res 2007; 19: 517–520.
Aksoy N, Aksoy M, Bagci C, Gergerlioglu HS, Celik H, Herken E et al. Pistachio intake increase high density lipoprotein levels and inhibits low-density lipoprotein oxidation in rats. Tohoku J Exp Med 2007; 212: 43–48.
Sullivan ME, Keoghane SR, Miller MA . Vascular risk factors and erectile dysfunction. BJU Int 2001; 87: 838–845.
Tanner FC, Noll G, Boulanger CM, Luscher TF . Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation 1991; 83: 2012–2020.
Rosenfeld ME . Oxidized LDL affects multiple atherogenic cellular responses. Circulation 1991; 83: 2137–2140.
Kugiyama K, Kerns SA, Morrisett JD, Roberts R, Henry PD . Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 1990; 344: 160–162.
Leung WH, Lau CP, Wong CK . Beneficial effect of cholesterol-lowering therapy on coronary endothelium dependent relaxation in hypercholesterolaemic patients. Lancet 1993; 341: 1496–1500.
Azadzoi K, Saenz de Tejada I . Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1991; 146: 238–240.
Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN . Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930–937.
Pinnock CB, Stapleton AM, Marshall VR . Erectile dysfunction in the community: a prevalence study. Med J Aust 1999; 171: 353–357.
Manning M, Schmidt P, Juenemann KP, Alken P . The role of blood lipids in erectile failure. Int J Impot Res 1996; 8: 167.
Nikoobakht M, Pourkasmaee M, Nasseh H . The relationship between lipid profile and erectile dysfunction. Urol J 2005; 2: 40–44.
Roumeguere TH, Wespes E, Carpentier Y, Hoffmann P, Schulman CC . Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003; 44: 355–359.
Jones PJ, MacDougall DE, Ntanios F, Vanstone CA . Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol 1997; 75: 217–227.
Vajifdar BU, Goyal VS, Lokhandwala YY, Mhamunkar SR, Mahadik SP, Gawad AK et al. Is dietary fiber beneficial in chronic ischemic heart disease? J Assoc Physicians India 2000; 48: 871–876.
Kurowska EM, Carroll KK . Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr 1994; 124: 364–370.
Awada AB, Hartatia MS, Finka CS . Phytosterol feeding induces alteration in testosterone metabolism in rat tissues. J Nutr Biochem 1998; 9: 712–717.
Jeremy JY, Angelini GD, Khan M, Mikhailidis DP, Morgan RJ, Thompson CS et al. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc Res 2000; 46: 50–54.
The authors declare no conflict of interest.
About this article
Cite this article
Aldemir, M., Okulu, E., Neşelioğlu, S. et al. Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int J Impot Res 23, 32–38 (2011). https://doi.org/10.1038/ijir.2010.33
- pistachio nuts
- erectile dysfunction
- IIEF scores
- penile color Doppler ultrasound
- lipid profile
This article is cited by
Info Diabetologie (2015)
International Journal of Impotence Research (2011)