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Progress and Prospects: prospects of repeated pulmonary administration of viral vectors

Gene Therapy volume 16, pages 1059–1065 (2009)Cite this article

Abstract

Pulmonary gene therapy may ultimately cure diseases such as cystic fibrosis, α1-antitrypsin deficiency, lung cancer and pulmonary hypertension. Efficient expression of delivered genes in target cell types is essential for the achievement of this goal. To this end, re-administration of viral vectors may be required (1) to increase the percentage of transduced airway epithelial cells, (2) to direct gene transfer to individual lobes during successive delivery sessions or (3) to boost attenuated expression over time. Immune responses to viral proteins or viral-encoded proteins are the greatest barrier to repeated vector administration.

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Authors and Affiliations

  1. Department of Pediatrics, Program in Gene Therapy, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA

    P L Sinn & P B McCray Jr

  2. Interdisciplinary Program in Genetics, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA

    E R Burnight & P B McCray Jr

Authors
  1. P L Sinn
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  2. E R Burnight
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  3. P B McCray Jr
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Correspondence to P B McCray Jr.

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Sinn, P., Burnight, E. & McCray, P. Progress and Prospects: prospects of repeated pulmonary administration of viral vectors. Gene Ther 16, 1059–1065 (2009). https://doi.org/10.1038/gt.2009.87

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