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Reassessment of the type I diabetes association of the OAS1 locus

Genes & Immunity volume 10, pages S69–S73 (2009)Cite this article

Abstract

To reassess the type I diabetes (T1D) association of the OAS1 locus, the Type I Diabetes Genetics Consortium (T1DGC) genotyped 11 tag single-nucleotide polymorphisms spanning ∼41 kb from the 5′ to 3′ flanking region. For each sample obtained from over 2000 affected sib-pair families from nine cohorts, the genotyping was performed on both the Illumina Golden Gate and Sequenom iPlex platforms. The data suggest that there may be a weak association with T1D for two OAS1 polymorphisms, rs3741981 and rs10774671, in populations of European descent. The OAS1 locus is close to a recently identified T1D-associated linkage disequilibrium (LD) block in human chromosome 12q24. Extended LD in populations earlier examined may account for the prior observation of an association of T1D with OAS1 variants. This possibility needs to be addressed further by fine mapping of the T1D association represented in 12q24.

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Acknowledgements

This research uses resources provided by the Type I Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. HQQ is supported by a fellowship from the Canadian Institutes of Health Research. We thank Dr John Todd for the helpful comments. Genotyping was performed at the Broad Institute Center for Genotyping and Analysis is supported by grant U54 RR020278 from the National Center for Research Resources.

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  1. Department of Pediatrics, McGill University, Montreal, Québec, Canada

    H-Q Qu & C Polychronakos

  2. Department of Human Genetics, McGill University, Montreal, Québec, Canada

    H-Q Qu & C Polychronakos

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  1. H-Q Qu
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the Type I Diabetes Genetics Consortium

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Correspondence to C Polychronakos.

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Qu, HQ., Polychronakos, C. & the Type I Diabetes Genetics Consortium. Reassessment of the type I diabetes association of the OAS1 locus. Genes Immun 10 (Suppl 1), S69–S73 (2009). https://doi.org/10.1038/gene.2009.95

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