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A transmembrane polymorphism in FcγRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA

Genes & Immunity volume 9, pages 680–688 (2008)Cite this article

Abstract

The aim of the current study was to determine whether the FcγRIIb 187-Ile/Thr polymorphism is a predisposition factor for subtypes of RA defined by disease severity and production of autoantibodies against cyclic citrullinated peptides (anti-CCPs) in Taiwanese RA patients. Genotype distributions and allele frequencies of FcγRIIb 187-Ile/Thr were compared between 562 normal healthy controls and 640 RA patients as stratified by clinical parameters and autoantibodies. Significant enrichment of 187-Ile allele was observed in RA patients positive for anti-CCP antibodies as compared with the anti-CCP negative RA patients (P=0.001, OR 1.652 (95% CI 1.210–2.257)) or as compared with the normal controls (P=0.005, OR 1.348 (95% CI 1.092–1.664)). In addition, 187-Ile allele was found to be enriched in RA patients positive for rheumatoid factor (RF) compared to the RF negative RA patients (P=0.024, OR 1.562 (95% CI 1.059–2.303)). Furthermore, the homozygotes were enriched in destructive male RA patients (P=0.035; OR 2.038 (95% CI 1.046–3.973)) and the 187-Ile allele was associated with early-onset of RA in Taiwanese patients (P=0.045, OR 1.548 (95% CI 1.007–2.379)). Thus, FcγRIIb SNP 187-Ile/Thr may influence the RA phenotypes in Taiwanese RA.

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Acknowledgements

We thank Shin Chu Blood Donor Center for sample collection and Dr Nengjun Yi for the help in statistical analysis. This study was supported by a grant from the Chang Gung Memorial Hospital (no. CMRPG 33070). Jianming Wu is partly supported by NIH Grant P01-AR49084.

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Authors and Affiliations

  1. Division of Allergy, Department of Medicine, Immunology and Rheumatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan, Republic of China

    J-Y Chen, C-C Ma, H-H Ho, Y-J J Wu & S-N Kuo

  2. Department of Rehabilitation, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan, Republic of China

    C-M Wang

  3. Department of Medicine, Division of First Cardiovascular, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan, Republic of China

    L-A Hsu

  4. Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    J Wu

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Chen, JY., Wang, CM., Ma, CC. et al. A transmembrane polymorphism in FcγRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA. Genes Immun 9, 680–688 (2008). https://doi.org/10.1038/gene.2008.56

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