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Bruch’s membrane opening-based optical coherence tomography of the optic nerve head: a useful diagnostic tool to detect glaucoma in macrodiscs

Abstract

Purpose

To compare Bruch’s membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) and margin based confocal scanning laser tomography (CSLT) of the optic nerve head (ONH) to visual field function in large optic discs (macrodiscs) and to assess performance for glaucoma detection.

Methods

In a case–control, cross-sectional study, 125 eyes of 125 patients with disc size >2.45 mm2, thereof 44 glaucoma and 11 ocular hypertension (OHT) patients and 70 healthy controls underwent SD-OCT and CSLT examination, visual field testing and clinical evaluation. Mean outcome measures BMO-based minimum rim width (BMO-MRW), retinal nerve fiber layer thickness (RNFLT) in SD-OCT, and rim area measured in CSLT were compared and correlated to visual field function.

Results

All participants had a mean disc area of 2.91±0.38 mm2 in CSLT and a BMO area of 2.45±0.39 mm2 (r=0.76;P<0.001). In glaucoma patients, visual field mean deviation was −10.0±6.1 dB. Global BMO-MRW correlated better to visual field function (Spearman’s Rho (ρ)=0.71; P<0.001) than RNFLT (ρ=0.52;P<0.001) and CSLT rim area (ρ=0.63; P<0.001). BMO-MRW was significantly decreased with higher visual field loss (P<0.001). In ROC analysis, diagnostic power to differentiate glaucoma patients and healthy controls was highest for BMO-MRW (Area under curve, AUC=0.96; sensitivity at 95% specificity=82%). Rim area in CSLT (AUC=0.91; sensitivity=61.0%; P=0.04) and RNFLT (AUC=0.89; sensitivity=61%; P=0.01) were significantly less powerful.

Conclusions

In macrodiscs, BMO-MRW has the best diagnostic power to discriminate glaucoma patients from normal controls compared to RNFLT and rim area in CSLT. Additionally, BMO-MRW seems to reflect the structure-function relationship better than the other two parameters.

Introduction

In very small or very large optic nerve heads diagnosis of glaucoma presents a major challenge for the clinician. In large optic discs, while the number of ganglion axons is equivalent or even higher compared to ‘regular’ sized discs, the neuroretinal rim in funduscopy seems thinned. Reason for this includes, that patients with large optic discs present physiologically a large irregular excavation of the optic nerve head.1, 2, 3

Morphometric analysis of the optic nerve head (ONH) and visual field testing represent the major keystones in diagnosis, treatment planning and follow-up of glaucoma patients.

Bruch’s membrane opening minimum rim width (BMO-MRW) as well as retinal nerve fiber layer thickness (RNFLT) analysis of the optic nerve head by Bruch’s membrane opening (BMO) based spectral domain optical coherence tomography (SD-OCT) becomes increasingly available to clinicians and proposes advantages compared to the previous clinical standard of morphometric optic nerve head analysis, confocal scanning laser tomography (CSLT) measurement.4, 5, 6 SD-OCT technique allows calculation of neuroretinal rim parameters based on the area of a surface extending from Bruch’s membrane opening (BMO) to the inner limiting membrane (ILM) and increasing validity by extending imaging to sub-surface structures.7 Besides other global and localized RNFLT measurements, global and sectorial mean minimum rim width parameters based on BMO (BMO-MRW) have been introduced and evaluated.4, 7, 8, 9, 10, 11, 12, 13, 14

Correlation of morphometric ONH parameters and visual field function has been evaluated in numerous studies.4, 15, 16, 17, 18, 19, 20, 21 Analyses aimed to explore individual correlation of morphometric ONH parameters as neuronal rim width to visual field parameters as mean deviation and to derive, if possible, a forecast of visual field defects based to ONH.

Qualification and quantification of the relation between structural damage to the ganglion axons in the optic nerve head and the functional, perimetric damage have been principal aim in glaucoma research. A recent study by Muth et al22 analyzed structure-function relationship between SD-OCT of the ONH and visual field testing in 46 eyes with random size of the optic disc.

The study contributes to the current effort to compare margin based rim area measurements from CSLT with BMO based measurements from SD-OCT. Recently, morphometric data for eyes with non-glaucomatous macrodiscs has been published by our group.23 Malik et al recently published an analysis on the diagnostic power in myopic discs; this group assessed the diagnostic power of one-dimensional SD-OCT-based morphometric parameters in microdiscs independent from refractive status.24, 25

The purpose of the present study is to assess the diagnostic power to detect glaucoma by OCT diagnostics of glaucomatous large optic nerve heads, so called macrodiscs (disc size>2.43 mm2 in CSLT). Further goal was to evaluate structure-function relationship of OCT-based morphometric data along different classifications of the glaucomatous visual field. Especially for large optic nerve heads, sufficient data is still missing.

Materials and methods

Data for this single-center retrospective analysis was acquired from September 2014 to March 2016 at the Department of Ophthalmology, University Clinic of Cologne, Germany. All consecutive patients receiving both CSLT as well as SD-OCT measurements of the optic nerve head were screened for size of the optic nerve head. Both measurements of one individual took place on the same day. For visual field testing a time gap of ±4 weeks was considered acceptable for inclusion.

Additional parameters were collected from patients’ files: Diagnosis of glaucoma, previous anti-glaucomatous surgery, best corrected visual acuity (BCVA), visual field testing, intraocular pressure (IOP), topical medication, and medical history of the eyes. IOP has been assessed by corneal rebound tonometry (Icare tonometer TA01i) and by Goldmann tonometry in adults and children, respectively.

Eyes with a large optic nerve head of more than 2.43 mm2 in CSLT were included in this study. This threshold was set by exceeding the upper limit for the normative collective in CSLT according to software version 3.1.0.2. The exclusion criteria were: visual field loss because of other etiologies than glaucoma, unsatisfactory image quality in CSLT, SD-OCT, or in visual field testing, and BCVA>0.4 logMAR. Only patients with primary open-angle glaucoma including pseudoexfoliation and pigmentary forms were included. For non-glaucomatous individuals, a mean deviation of better than −3 dB was required, following an outside expert guidance in peer review of the previous analysis on non-glaucomatous macrodiscs.23 If multiple data points at different time points were available, then the examination with the best imaging quality indicators was used. If both eyes fulfilled all inclusion criteria and no exclusion criteria, the eye with the larger disc size was selected.

One hundred twenty five eyes of 125 patients could be included in this study out of a source database of 220 eyes with macrodiscs. A total of 14 eyes lacked sufficient clinical information or quality of visual field testing, 28 eyes of non-glaucomatous controls exceed the defined limit for mean deviation in visual field of −3 dB. Further, 53 eyes have been excluded being the fellow of a patient with eligibility of both eyes.

Patients have been classified into three different diagnostic groups according to the 4th Edition of Guidelines of the European Glaucoma Society (EGS, 2014): (1) Glaucoma patients; (2) patients with ocular hypertension (OHT); and (3) individuals with no suspicion of glaucoma.26 In EGS guidelines, glaucomas are progressive optic neuropathies that have in common characteristic morphological changes at the optic nerve head and retinal nerve fibre layer in the absence of other ocular disease of congenital anomalies. Progressive ganglion cells death and visual field loss are associated with the changes. For glaucoma patients included in this study, beginning changes in visual field assessment were required.

CSLT and SD-OCT examinations were executed by Heidelberg Engineering Retina Tomograph III and Spectralis SD-OCT (Heidelberg Engineering GmbH, Heidelberg, Germany) following standard operating procedures. Two independent evaluators (EP, SF) assessed image quality and—in CSLT—defined the disc margin manually; threshold for the SD of the CSLT topography was set<40 μm. SD-OCT data included comprised an image quality index of>15 dB. In case of a significant discrepancy between the disc margins drawn by the operators, the images were reevaluated until consensus was achieved. The neuroretinal rim was calculated automatically by using the CSLT standard reference plane. SD-OCT imaging was performed with a commercially available Heidelberg Spectralis device. A light source of 870 nm was used according to standard imaging procedure. The scanning pattern was centered on the optic disc with radial equidistance (24-high resolution 15° radial scans, each averaged from 27 B-scans). The examiners controlled the centration of the scan to the optic disc and corrected errors in detection of internal limiting membrane (ILM) and Bruch’s membrane opening. OCT-based parameters were calculated by the device operating software tool provided by Heidelberg Engineering, including a data export batch provided by the manufacturer.

Visual field testing at the site was performed using a Octopus 101 visual field analyzer (Haag-Streit AG, Koeniz, Switzerland) with a 30/2 TOP white-on-white standard pattern and analyzed by Peridata 3.1. Age and refraction matching lens correction was applied, visual field testing was performed separately for both eyes. Thresholds for reliability were set at ≤30% for false positive and false-negative answers as well as≤20% for fixation losses.

Visual field results were screened manually for glaucomatous scotoma and classified according to Aulhorn and Karmeyer.27, 28, 29 Additionally, patients were classified based on a simplified modification of the Hodapp–Anderson–Parrish system:30 Patients were divided into three groups depending on their global mean deviation in perimetry as output parameter. (MD-G). A more negative number indicates a higher loss in function. The groups are: early glaucoma (MD-G equal to or above −6 dB), moderate glaucoma (MD-G below −6 dB but equal to or above −12 dB), and severe glaucoma (MD-G below −12 dB).

According to national medical regulations on retrospective single center clinical studies Ethics Committee of the University of Cologne ruled that approval was not required for this study. All tenets of the declaration of Helsinki have been regarded.

Statistical analysis was performed by SPSS Version 22.0 (IBM Corp. Armonk, NY, USA), the statistical programming language R V3.2.2 (R Foundation for Statistical Computing, Vienna, Austria and by MedCalc Statistical Software Version 16.4.3 (MedCalc Software Bvba, Ostend, Belgium; https://www.medcalc.org; 2016). Pearson correlation coefficient r and Spearman rank correlation coefficient ρ were used depending on normal distribution of parameters. Diagnostic power was assessed by receiver operating characteristic (ROC) analysis and tested for statistically significant difference with DeLong test. Threshold for statistical significance was set at P<0.05. Threshold for statistical significance was set at P<0.05. Holm–Bonferroni procedure was used to correct P-values for multiple testing.31

Results

Out of 125 eyes of 125 patients included in this study with macrodiscs, glaucoma has been diagnosed in 44 (35.2%) patients; ocular hypertension was present in 11 (8.8%), while 70 (56.0%) individuals had clinically no suspicion of glaucoma. Table 1 summarizes the epidemiologic characteristics and baseline data of the included eyes clustered by diagnoses.

Table 1 Epidemiological and baseline data

Eyes with macrodiscs and glaucoma

In 44 eyes with glaucomatous macrodiscs, mean disc size (±SD) in CSLT was 2.71±0.80 mm2 (range, 2.44–3.72 mm2) and BMO area was 2.41±0.34 mm2 (range, 1.93–3.42 mm2).

Mean BMO-MRW was 124.3±42.5 μm (range, 59.87–242.17 μm), mean RNFLT was 54.41±15.4 μm (range, 27–102 μm), and mean rim area in CSLT was 0.86±0.36 mm2 (range, 0.23–1.73 mm2). Correlation between disc size in CSLT and BMO area was significant (r=0.71; P<0.001).

Pearson correlation coefficient between BMO-MRW and mean rim area in CSLT was r=0.80 (P<0.001), and between RNFLT and BMO-MRW r=0.75 (P<0.001), respectively. Correlation between RNFLT and mean rim area in CSLT was smaller with r=0.57 (P<0.001). Table 2 displays the morphometric data with global and sectorial analyses.

Table 2 Confocal scanning laser tomography (CSLT) and spectral domain optical coherence tomography (SD-OCT) based neuroretinal rim parameters including six optic nerve sectors

In Spearman non-parametric correlation, the parameter BMO-MRW correlates better to visual field function parameter mean deviation (ρ=0.71; P<0.001) than the two other examined morphometric factors RNFLT (ρ=0.52; P<0.001) and rim area of CSLT (ρ=0.63; P<0.001). Mean BMO-MRW values were evaluated along the two introduced visual field classifications in glaucoma. In Hodapp-Anderson-Parrish system, mean BMO-MRW decreased significantly from 157.88±47.2 μm in stage 1 to 114.64±29.5 μm in stage 2 and 102.71±29.9 μm in stage 3. (P=0.002, Jonckheere–Terpstra test; Figure 1). In degrees of Aulhorn classification, mean minimum rim width in OCT decreased from 162.65±47.3 μm in degree 1 to 118.74±26.0 μm in degree 2, 100.88±21.6 μm in degree 3, 106.58±38.5 μm in degree 4 and 94.27±17.7 μm in degree 5. (P<0.001, Jonckheere–Terpstra test; Figure 2).

Figure 1
figure1

Global Bruch’s membrane opening-based minimum rim width in visual field classifications: Hodapp stages. Note: boxplot graphs display global Bruch’s membrane opening-based minimum rim width (BMO-MRW) medians and ranges for three different stages of the Hodapp classification for glaucomatous visual field defects.

Figure 2
figure2

Global Bruch’s membrane opening-based minimum rim width in visual field classifications: Aulhorn degrees. Note: boxplot graphs display global Bruch’s membrane opening-based minimum rim width (BMO-MRW) medians and ranges for different degrees of glaucomatous visual field defects according to Aulhorn classification.

Eyes with macrodiscs and ocular hypertension

In 11 eyes with macrodiscs and ocular hypertension, mean disc size in CSLT was 2.95±0.41 mm2 (range, 2.50–3.83 mm2), mean BMO area was 2.40±0.44 mm2 (range, 1.16–3.04 mm2). Mean global BMO-MRW was 226.38 μm (range, 177.9–302.4 μm), mean RNFLT was 72.3±15.2 μm (range, 49–106 μm), and mean rim area in CSLT was 1.66±0.39 mm2 (range, 1.22–2.20 mm2). Disc area in CSLT and BMO correlated strongly (r=0.88, P<0.001). Table 2 displays the morphometric data with global and sectorial analyses.

Normal controls with macrodiscs

In 70 eyes of non-glaucomatous controls, mean disc size in CSLT was 2.98±0.41 mm2 (range, 2.45–4.23 mm2), and mean BMO area was 2.50±0.40 mm2 (range, 1.81–3.35 mm2). Mean global BMO-MRW was 243.1±44.1 μm (range, 120.1–350.0 μm), mean RNFLT was 82.7±15.8 μm (range, 37–110 μm) and mean rim area in CSLT was 1.54±0.34 mm2 (range, 0.74–2.51 mm2).

Disc area in CSLT and BMO area correlated strongly (r=0.83, P<0.001). Table 2 displays the morphometric data with global and sectorial analyses.

Comparative analysis between diagnostic groups

In ROC analysis for diagnostic power to discriminate glaucoma patients and non-glaucomatous controls, BMO-MRW demonstrated the highest area under curve (AUC) at 0.96, while sensitivity at 95% specificity was 84%. Diagnostic power of rim area in CSLT (AUC=0.91; sensitivity=60%; P=0.01) and peripapillary RNFLT (AUC=0.89; sensitivity=63%; P=0.04) were significantly less powerful to detect glaucoma. There was no statistical significant difference between AUCs of rim area in CSLT and peripapillary RNFLT (P=0.6).

Mean age of glaucoma patients (68.4 years) and non-glaucomatous controls (38.8 years) differed significantly (P<0.001). A subsequent analysis was performed including only patients 45 years of age and older in both groups. In 44 glaucoma patients with macrodiscs and 29 controls, mean age was comparable (P=0.06). In ROC analysis, AUC of BMO-MRW was 0.93, AUC of rim area in CSLT was 0.89 and AUC of RNFLT was 0.83, respectively. While the difference between BMO-MRW and RNLFT remains statistically significant with P=0.03, level of significance was not reached for the difference of BMO-MRW and rim area in CSLT.

Figure 3 displays ROC-analysis for BMO-MRW, RNFL and rim area in CSLT for all glaucoma patients and non-glaucomatous controls. Cutoff points at 95% specificity were 211.8 μm for BMO-MRW, 76.5 μm for RNFL and 1.48 mm2 for rim area in CSLT.

Figure 3
figure3

ROC analysis: discrimination of glaucoma patients from normal controls by BMO-MRW, RNFL (OCT) and CSLT rim area with sensitivities at 95%-specificity. Legend: ROC, Receiver Operator Characteristic; BMO-MRW, Bruch’s membrane opening-based minimum rim width; RNFLT, Retinal nerve fiber layer thickness; CSLT, confocal scanning laser tomography.

Discussion

BMO-based SD-OCT of the optic nerve head plays an increasingly important role as diagnostic tool, bearing major advantages compared to previous techniques.11, 12, 13 BMO-MRW showed highest sensitivity in discrimination of glaucoma patients from normal controls out of all currently clinically available parameters.13 New morphometric parameters such as BMO-based minimum rim area (BMO-MRA) are currently in evaluation.4, 22 Structure function relationship was analyzed in multiple studies.14, 32, 33, 34

In SD-OCT morphometry, data on special configurations of the optic disc is currently in scope of different research groups, especially for very small or very large discs, myopic discs, tilting of the disc as well as other papillary anomalies. Recently, we have published data on 102 controls in SD-OCT analysis of the optic nerve head in non-glaucomatous large optic discs.23 For small optic disc as well as for myopic discs, diagnostic power of BMO-based parameters has been analyzed as well.24, 25

For glaucomatous macrodiscs data was still missing. Our aim was to add OHT and glaucoma patients to the existing database. For non-glaucomatous individuals with macrodiscs BMO-based minimum rim width and RNFLT are thinner.22 Patients with regular visual field function and ocular hypertension did not show a significant decrease of BMO-MRW or RNFL compared to normal controls.

In the present study, BMO-MRW showed highest sensitivity to discriminate glaucoma patients from normal controls. Unlike in other special disc situations (ie,, myopic discs or microdiscs), peripapillary RNFLT measurement did not seem to represent an additional diagnostic aid as comprising the significantly lowest AUC. Within the aged-match control group, overall AUCs were higher than in microdiscs.25 Furthermore, BMO-MRW is more powerful to assess the functional defects in visual field testing compared to the other morphometric parameters RNFLT and rim area in CSLT.22 Along visual stages in visual field classifications Hodapp-Anderson-Parris and Aulhorn, BMO-MRW decreases significantly with loss of function. An individual, patient-specific predictability of the structure-function relationship is limited due to the large variation within those parameters as well as learning effects in visual field testing.35

Limitations of our study include the retrospective study set-up, only one available visual field test result as well as a potential selection bias due to patient exclusion due to data inconsistencies. Epidemiologic and baseline data of the study group reflected a characteristic pattern of glaucoma patients.

In summary, for large optic discs, so called macrodiscs, the BMO-based parameter minimum rim width assessed by SD-OCT has the best diagnostic power to detect glaucoma compared to other clinically available morphometric parameters and reflects best structure-function relationship.

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Acknowledgements

We thank all technical experts of our imaging laboratory and well as FOR 2240 for their support.

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Enders, P., Schaub, F., Adler, W. et al. Bruch’s membrane opening-based optical coherence tomography of the optic nerve head: a useful diagnostic tool to detect glaucoma in macrodiscs. Eye 32, 314–323 (2018). https://doi.org/10.1038/eye.2017.306

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