Abstract
Purpose To assess the effects of histocompatibility Y (H-Y) antigen matching on the rate of corneal allograft rejection after penetrating keratoplasty (PKP).
Methods We retrospectively investigated the graft survival rate and rejection-free graft survival rate after PKP in 396 eyes. The compatible combinations of H-Y antigen included male donors and male recipients (n = 135), female donors and male recipients (n = 107), and female donors and female recipients (n = 60). Incompatible combination was from male donors and female recipients (n = 94). The eyes were classified into two groups - high-risk (168 eyes) and low-risk (228 eyes) - depending on the degree of vascularisation in the recipient corneas or a history of previous allograft rejection. Data were analysed using the Kaplan-Meier life table method, the log- rank test and the Cox proportional hazards model.
Results In both the high-risk and low-risk groups, the graft survival and rejection-free graft survival rates were not affected by the H-Y compatibility. The graft survival (p < 0.001) and rejection-free graft survival (p < 0.001) rates were higher in the low-risk group than in the high-risk group. High-risk PKP was associated with greater risk of graft failure (risk ratio, 2.33) and rejection (risk ratio, 2.05) than low-risk PKP.
Conclusion H-Y antigen matching does not influence the rate of allograft rejection after PKP.
Similar content being viewed by others
Article PDF
References
Yamagami S, Suzuki T, Tsuru T . Multivariate analysis of risk factors of allograft rejection in penetrating keratoplasty. Jpn J Ophthalmol 1994;38:311–6.
Borderie VM, Lopez M, Vedie F, Laroche L . ABO antigen blood-group compatibility in corneal transplantation. Cornea 1997;16:1–6.
Boisjoly HM, Raynald R, Bernard PM, Dube I, Laughrea PA, Bazin R . Association between corneal allograft reaction and HLA compatibility. Ophthalmology 1990;97:1689–98.
Sanfilippo F, MacQueen JM, Vaughn WK, Foulks GN . Reduced graft rejection with good HLA-A and -B matching in high-risk corneal transplantation. N Engl J Med 1986;315:29–35.
Batchelor JR, Casey TA, Werb A, Gibbs DC, Prasad SS, Lloyd DF, et al. HLA matching and corneal grafting. Lancet 1976;1:551–4.
Loveland B, Simpson E . The non-MHC transplantation antigens: neither weak nor minor. Immunol Today 1986;7:223–9.
Lindahl KF . Minor histocompatibility antigens. Trends Genet 1991;7:219–24.
Maguire MG, Stark WJ, Gottsch JD, Stulting RD, Sugar A, Fink NE, et al. Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies: Collaborative Corneal Transplantation Studies Research Group. Ophthalmology 1994;101:1536–47.
Collaborative Corneal Transplantation Studies (CCTS) Research Group. Effectiveness of histocompatibility matching in high-risk corneal transplantation. Arch Ophthalmol 1992;110:1392–403.
Eichwald EJ, Slimser CR . Transplant Bull 1955;2:148–9.
Billingham RE, Silvers WK . Studies on tolerance of the Y chromosome antigen in mice. J Immunol 1960;85:14–26.
Cantrell MA, Bogan JS, Simpson E, Bicknell JN, Goulmy E, Chandler P, et al. Deletion mapping of H-Y antigen to the long arm of the human Y chromosome. Genomics 1992;13:1255–60.
Kawauchi M, Gundry SR, de Begona JA, Fullerton DA, Razzouk AJ, Boucek MM, et al. Male donor into female recipient increases the risk of pediatric heart allograft rejection. Ann Thorac Surg 1993;55:716–8.
Goulmey E, Termijtelen A, Bradley BA, Van Rood JJ . Y-antigen killing by T-cells of women is restricted by HLA. Nature 1997;266:544–5.
Goulmey E, Bradley A, Lansbergen Q, Van Rood JJ . The importance of H-Y incompatibility in human organ transplantation. Transplantation 1978;25:315–9.
Candinas D, Gunson BK, Hubscher S, McMaster P, Neuberger JM . Sex mismatch as a risk factor for chronic rejection of liver allografts. Lancet 1995;346:1117–21.
Pfeffer PF, Thorsby E . HLA-restricted cytotoxicity against male-specific (H-Y) antigen after acute injection of an HLA identical sibling kidney. Transplantation 1982;33:52–6.
Ellison MD, Norman DJ, Breen TJ, Edwards EB, Davies DB, Daily OP . No effect of H-Y minor histocompatibility antigen in zero-mismatched living-donor renal transplants. Transplantation 1994;58:518–30.
Opelz G, Terasaki PI . Influence of sex on histocompatibility matching in renal transplantation. Lancet 1977;1:419–21.
Goulmy E, Pool J, Van Lochehm E, Volker-Dieben H . The role of human minor histocompatibility antigens in graft failure: a mini-review. Eye 1995;9:180–4.
Ray-Keil L, Chandler JW . Rejection of marine heterotopic corneal transplants. Transplantation 1985;39:473–7.
He YG, Ross J, Callanan D, Niederkorn JY . Acceptance of H-Y-disparate corneal grafts despite concomitant immunisation of the recipient. Transplantation 1991;51:1258–62.
Kaplan EL, Meier P . Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457.
Cox DR . Regression models and life tables. J R Stat Soc 1972;34:187–220.
Havener WH, Stine GT, Weiss LL . Corneal donor selection by blood type. Arch Ophthalmol 1958;60:443–7.
Mehri P, Becker B, Oglesby R . Corneal transplants and blood types. Am J Ophthalmol 1959;47:48–53.
Allansmith MR, Drell DW, Kajiyama G, Fine M . ABO blood groups and corneal transplantation. Am J Ophthalmol 1975;79:493–501.
Volker-Dieben HJ, Kok-Van Alphen CC, Landsbergen Q Persijin GG . Different influences on corneal graft survival in 539 transplants. Acta Ophthalmol (Cophenh) 1982;60:190–202.
Cherry PMH, Pashby RC, Tadros ML, Wolf A, Chipman ML, Basu PK, et al. An analysis of corneal transplantation - I. Graft clarity. Ann Ophthalmol 1979;11:461–9.
Volker-Dieben HJ, D'Amaro J, Kok-Van Alphen CC . Hierarchy of prognostic factors for corneal allograft survival. Aust N Z J Ophthalmol 1987;15:11–18.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Inoue, K., Amano, S., Oshika, T. et al. Histocompatibility Y antigen compatibility and allograft rejection in corneal transplantation. Eye 14, 201–205 (2000). https://doi.org/10.1038/eye.2000.54
Issue Date:
DOI: https://doi.org/10.1038/eye.2000.54
Keywords
This article is cited by
-
Gender medicine in corneal transplantation: influence of sex mismatch on rejection episodes and graft survival in a prospective cohort of patients
Cell and Tissue Banking (2021)
-
Impact of donor–recipient gender on kidney graft and patient survival: short- and long-term outcomes
World Journal of Urology (2014)
-
Matching von Minor-Transplantationsantigenen in der perforierenden Keratoplastik
Der Ophthalmologe (2007)
-
Changing assumptions about the mechanism of corneal transplant rejection
Eye (2000)