Abstract
Although the eye is considered to be immunologically privileged, this privilege is not absolute. This is well demonstrated by, for example, the fate of corneal transplantations. Clinical studies in man and experimental studies in animals have shown that survival of a corneal transplant depends on the local condition of the cornea and the anterior chamber of the eye. The presence of neovascularisation or Langerhans cells in the recipient cornea endangers the graft, while the intracorneal production of immunosuppressive factors may inhibit the development of rejection. The balance between suppressive and stimulatory factors determines whether a local immune response will develop.
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Medawar PB . Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 1948;29:58–67.
Niederkorn JY, Peeler JS . Regional differences in immune regulation: the immunogenic privilege of corneal allografts. Immunol Res 1988;7:247–55.
Katami M, Graudenz MS, White DJG, Watson PG . The role of antigen-presenting cells in rat corneal graft rejection. Transplant Proc 1991;23:93–5.
Callanan D, Peeler J, Niederkorn JY . Characteristics of rejection of orthotopic corneal allografts in the rat. Transplantation 1988;45:437–43.
Völker-Dieben J, D'Amaro J, Kok-van Alphen CG Hierarchy of prognostic factors for corneal allograft survival. Aust NZ J Ophthalmol 1987;15:ll–8.
Jager MJ, Hermans LJA, Dake CL, Gortzak-Moorstein N, Kok JHC, D'Amaro J . Follow-up of corneal transplantations at the Academic Medical Centre of Amsterdam. Doc Ophthalmol 1988;70:137–44.
Williams KA, Roder D, Esterman A, Muehlberg SM, Coster DJ . Factors predictive of corneal graft survival: -report from the Australian Corneal Graft Registry. Ophthalmology 1992;99:403–14.
Völker-Dieben HJ, D'Amaro J, Kruit PJ, Lange P de. Interaction between prognostic factors for corneal allograft survival. Transplant Proc 1989;21:3135–8.
Khodadoust AA, Silverstein AM . Studies on the nature of the privilege enjoyed by corneal allografts. Invest Ophthalmol 1972;ll:137–48.
Williams KA, Coster DJ . Penetrating corneal transplantation in the inbred rat: a new model. Invest Ophthalmol Vis Sci 1985;26:23–30.
Jager MJ . Corneal Langerhans cells and ocular immunology. Reg Immunol 1992;4:186–95.
Gillette TE, Chandler JW, Greiner JV Langerhans cells of the ocular surface. Ophthalmology 1982;89:700–ll.
Delbosc B, Fellmann D, Piquot X, Montard M, Royer J . Antigenicitè HLA des cornèes humaines normales et pathologiques. J Fr Ophtalmol 1990;13:535–41.
Niederkorn JY, Peeler JS, Ross J, Callanan D . The immunogenic privilege of corneal allografts. Reg Immunol 1989;2:117–24.
Berman B, France DS, Martinelli GP, Hass A . Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorti-costeroids. J Invest Dermatol 1983;80:168–71.
Lang RM, Friedlaender MH, Schoenrock BJ . A new morphologic manifestation of Langerhans cells in guinea pig corneal transplants. Curr Eye Res 1981;l:161–7.
Russell RG, Nasise MP, Larsen HS, Rouse BT . Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci 1984;25:938–44.
McLeish W, Rubsamen P, Atherton SA, Streilein JW . Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. Reg Immunol 1989;2:236–43.
Kamenar T, Asbell PA . The effect of thermal burns on Langerhans cells and herpes keratitis. Invest Ophthalmol Vis Sci 1988;29(Suppl):433.
Jager MJ, Atherton S, Bradley D, Streilein JW . Role of corneal Langerhans cells in the development of herpetic stromal keratitis in mice. Curr Eye Res 1991;10(Suppl):69–73.
Streilein JW . Anterior chamber associated immune deviation: the privilege of immunity in the eye. Surv Ophthalmol 1990;35:67–73.
Williamson JSP, DiMarco S, Streilein JW . Immunobiology of Langerhans cells on the ocular surface. I. Langerhans cells within the central cornea interfere with induction of anterior chamber associated immune deviation. Invest Ophthalmol Vis Sci 1987;28:1527–32.
Granstein RD, Staszewski R, Knisely TL, Zeira E, Nazareno R, Latina M, Albert DM . Aqueous humour contains transforming growth factor-β and a small (<3500 daltons) inhibitor of thymocyte proliferation. J Immunol 1990;144:3021–7.
Fontana A, Constam DB, Frei K, Malipiero U, Pfister HW . Modulation of the immune response by transforming growth factor beta. Int Arch Allergy Immunol 1992;99:l–7.
Helbig H, Kittredge KL, Coca-Prados M, Davis J, Palestine AG, Nussenblatt RB . Mammalian ciliarybody epithelial cells in culture produce transforming growth factor-beta. Graefe's Arch Clin Exp Ophthalmol 1991;229:84–7.
Knisely TL, Bleicher PA, Vibbard CA, Granstein RD . Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr Eye Res 1991;10:761–71.
Wilbanks GA, Streilein JW . Suppression of delayed hypersensitivity in vivo by an ACAID-inducing signal created in vitro. Invest Ophthalmol Vis Sci 1992;33(Suppl):1283.
Wilbanks GA, Streilein JW . Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-beta. Eur J Immunol 1992;22:1031–6.
Okamoto S, Streilein JW . ACAID-inhibiting properties of selected pro-inflammatory factors (abs. JERMOV 1994, p. 194).
BenEzra D, Sachs U . Growth factors in aqueous humour of normal and inflamed eyes of rabbits. Invest Ophthalmol Vis Sci 1973;13:868–70.
Kaiser CJ, Ksander BR, Streilein JW . Inhibition of lymphocyte proliferation by aqueous humour. Reg Immunol 1989;2:42–9.
Streilein JW, Bradley D . Analysis of immunosuppres-sive properties of iris and ciliary body cells and their secretory products. Invest Ophthalmol Vis Sci 1991;32:2700–10.
Knisely TL, Hosoi J, Nazareno R, Granstein RD . The presence of biologically significant concentrations of glucocorticoids but little or no cortisol binding globulin within aqueous humour: relevance to immune privilege in the anterior chamber of the eye. Invest Ophthalmol Vis Sci 1994;35:3711–23.
Sano Y, Streilein JW . Effects of corneal surgical wounds on ocular immune privilege. In Nussenblatt RB et al, eds. Advances in ocular immunology. Amsterdam: Elsevier, 1994;207–10.
Jager MJ, Bradley D, Streilein JW . Immunosuppressive properties of human cornea and iris/ciliary body in normal and pathological conditions. Transplant Immunol 1995; (in press).
Williams KA, Ash JK, Coster DJ . Histocompatibility antigen and passenger cell content of normal and diseased human cornea. Transplantation 1985,39:265–9.
Williams KA, White MA, Ash JK, Coster DJ . Leukocytes in the graft bed are associated with corneal graft failure: analysis by immunohistology and actuarial graft survival. Ophthalmology 1989;96:38–44.
Wilson SE, Lloyd SA . Epidermal growth factor, transforming growth factor beta-1, and interleukin-la messenger RNA production in human corneal endothelial cells. Invest Ophthalmol Vis Sci 1991;32:2747–56.
Donnelly JJ, Chan LS, Xi M-S, Rockey JH . Effect of human corneal fibroblasts on lymphocyte proliferation in vitro. Exp Eye Res 1988;47:61–70.
Young E, Stark WJ . In vitro immunological function of human corneal fibroblasts. Invest Ophthalmol Vis Sci 1988;29:1402–6.
Donnelly JJ, Zi MS, Rockey JH . A soluble product of human corneal fibroblasts inhibits lymphocyte activation: enhancement by interferon-gamma. Exp Eye Res 1993;56:157–65.
Shams NBK, Huggins EM, Sigel MM . Regulation of mitogen-driven lymphoreticular cell activation by human corneal cells and interleukin-1. Cornea 1993;12:46–53.
Obritsch WF, Kawashima H, Evangelista A, Ketcham JM, Holland EJ, Gregerson DS . Inhibition of in vitro ? cell activation by corneal endothelial cells. Cell Immunol 1992;144:80–94.
Kawashima H, Obritsch WF, Gregerson DS . Corneal endothelial cells create and maintain a unique microenvironment for immune cells. Reg Immunol, in press.
Kawashima H, Gregerson DS . Corneal endothelial cells block T cell proliferation, but not T cell activation or responsiveness to exogenous IL-2. Curr Eye Res 1994;13:575–85.
Kawashima H, Prasad SA, Gregerson DS . Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production.J Immunol 1994;153:1982–9.
Kawashima H, Gregerson DS . Corneal endothelial cells block IL-2 production, but not IL-2 receptor upregulation of T cells. In Nussenblatt RB et al, eds. Advances in ocular immunology. Amsterdam: Elsevier, 1994;11–15.
Shams NBK, Huggins EM, Sigel MM . Interleukin-1 regulates the proliferation of leucocytes in human corneal cell-peripheral blood leukocyte cocultures. Cornea 1994;13:9–15.
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Jager, M., Gregerson, D. & Streilein, J. Regulators of immunological responses in the cornea and the anterior chamber of the eye. Eye 9, 241–246 (1995). https://doi.org/10.1038/eye.1995.47
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DOI: https://doi.org/10.1038/eye.1995.47
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