Sickle trait is traditionally considered a benign condition by ophthalmologists. Three cases of sickle retinopathy in subjects with sickle trait are reported. In all cases the onset of retinopathy was related to other contributing factors: in one case a traumatic hyphaema and raised intraocular pressure, in two others diabetes mellitus. Patients with sickle trait are at risk of retinopathy if coincident ocular or systemic disease is present.
Myerson RM, Harrison E, Lohmuller HW . Incidence and significance of abnormal haemoglobins. Am J Med 1959;26:543.
Lieb WA, Geeraets WJ, Guerry D III. Sickle cell retinopathy: ocular and systemic manifestations of sickle cell disease. Acta Ophthalmol (Copenh) 1959;58(Suppl):3–45.
Isbey EK Jr, Clifford GO, Tanaka KR . Vitreous haemorrhage. Am J Ophthalmol 1958;45:870–9.
Kennedy JJ, Cope CB . Intraocular lesions associated with sickle cell disease. Arch Ophthalmol 1947;58:163–8.
Nagpal KC, Asdourian GK, Patrianakos D, et al. Proliferative retinopathy in sickle-cell trait. Arch Intern Med 1977;137:325–8.
Dean J, Schechler AN . Sickle-cell anaemia: molecular and cellular basis of therapeutic approaches. N Engl J Med 1978;299:753, 804-11, 863-70.
Inomata H, Bill A, Smelser G . Aqueous humour pathways through the trabecular meshwork and into Schlemm's canal in the cynomolgus monkey (Macaca irus): an electron microscope study. Am J Opthalmol 1972;73:760–89.
Harris JW . The role of physical and chemical factors in the sickling phenomenon. Prog Hematol 1959;2:47–109.
Ham TH, Castle WB . Relation of increased hypotonic fragility and of erythrostasis in the mechanism of hemolysis in certain anaemias. Trans Assoc Am Physicians 1940;55:127–32.
Cook WC . A case of sickle cell anaemia with associated subarachnoid haemorrhage. J Med 1930;11:541.
Hannon JF . Vitreous haemorrhage associated with sickle cell haemoglobin C disease. Am J Ophthalmol 1956;42:707–12.
Henry MD, Chapman AZ . Vitreous haemorrhage and retinopathy associated with sickle-cell disease. Am J Ophthalmol 1954;38:204–9.
Kabakow B, Van Weimokly SS, Lyons HA . Bilateral central retinal artery occlusion: occurrence in a patient with cortisone treated systemic lupus erythematosus, sickle-cell trait and active pulmonary tuberculosis. Arch Ophthalmol 1955;54:670–6.
Conrad WC, Penner R . Sickle-cell trait and central retinal artery occlusion. Am J Ophthalmol 1967;63:465–8.
Stein MR, Gay AJ . Acute chorioretinal infarction in sickle-cell trait: report of a case. Arch Ophthalmol 1970;84:485–90.
McMillan DE, Utterback NG, La Puma J . Reduced erythrocyte deformability in diabetes. Diabetes 1978;27:895–901.
Goldberg MF . The diagnosis and treatment of secondary glaucoma after hyphema in sickle-cell patients. Am J Ophthalmol 1979;87:43–9.
Wax MB, Ridley ME, Magargal LE . Reversal of retinal and optic disc ischemia in a patient with sickle-cell trait and glaucoma secondary to traumatic hyphema. Ophthalmology 1982;89:845–51.
Michelson PE, Pfaffenbach D . Retinal arterial occlusion following ocular trauma in youths with sickle-trait hemoglobinopathy. Am J Ophthalmol 1972;74:494–7.
Sorr EM, Goldberg RE . Traumatic central retinal artery occlusion with sickle cell trait. Am J Ophthalmol 1975;80:648–52.
Radius RL, Finkelstein D . Central retinal artery occlusion (reversible) in sickle trait with glaucoma. Br J Ophthalmol 1976;60:428–30.
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Jackson, H., Bentley, C., Hingorani, M. et al. Sickle retinopathy in patients with sickle trait. Eye 9, 589–593 (1995). https://doi.org/10.1038/eye.1995.145
- Raised intraocular pressure
- Sickle trait