Abstract
Acanthosis nigricans classically presents with pigmented skin lesions over the neck, groin and axillae. It may involve the mucosal surfaces, particularly the oral mucosa. conjunctival involvement is very rare, especially in the variety associated with malignancy. We report a case of acanthosis nigricans associated with squamous cell carcinoma of the bronchus where bilateral papillary conjunctivitis, progressing to hypertrophic papillary conjunctival and lid margin lesions, was the presenting feature. Topical treatment with corticosteroid and artificial tear drops resulted in the partial improvement of the ocular symptoms.
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Pollitzer S . In: Unna PG, et al., editors. Internationaler Atlas seltener Hautkrankheiten. Leipzig: Leopold Voss, 1890:plate 10.
Janovsky V . In: Unna PG, et al., editors. Internationaler Atlas seltener Hautkrankheiten. Leipzig: Leopold Voss, 1890:plate 11.
Sams WM, Lynch PJ . Principles and practice of dermatology. New York. Churchill Livingstone, 1990:663, 719, 737.
Cohen PR, Grossman ME, Almeida L, Kurzrock R . Tripe palms and malignancy. J Clin Oncol 1989;7:669–78.
Brown J, Winkelmann R . Acanthosis nigricans: a study of 90 cases. Medicine 1968;47:33–51.
Duke Elder S . Systems of ophthalmology, vol 8, part 1. London: Kimpton, 1965;550–1.
Weiss A . Erkrankungen des Auges bei Acanthosis nigricans. Klin Monatsbl Augenheilk 1927;78:790–6.
Friedlaender MH . Some unusual nonallergic causes of giant papillary conjunctivitis. Trans Am Ophthalmol Soc 1990;88:343–51.
Allansmith MR, Korb DR, Greiner JV, Henriquez AS, Simon MA, Finnemore VM . Giant papillary conjunctivitis in contact lens wearers. Am J Ophthalmol 1977;83:697–708.
Srinivasan BD, Jakobiec FA, Iwamoto T, DeVoe AG . Giant papillary conjunctivitis with ocular prostheses. Arch Ophthalmol 1979;97:892–5.
Toyama J . Beitrag zur Kenntnis der Acanthosis nigricans. Dermat Zeitschr 1913;20:785–95.
Birch-Hirschfeld, Kraft OH . Ueber Augenerkrankung bei Acanthosis nigricans. Klin Monatsbl Augenheilk 1904;42:232–40.
Burmeister J . Ueber einen neuen Fall von Acanthosis nigricans. Arch Derm Syph 1899;47:343–68.
Curth H, Aschner B . Genetic studies on acanthosis nigricans. Arch Dermatol 1959;79:55–66.
Matsuoka LY, Wortsman J, Gavin JR, Goldman J . Spectrum of endocrine abnormalities associated with acanthosis nigricans. Am J Med 1987;83:719–25.
Stuart CA, Pate CJ, Peters EJ . Prevalence of acanthosis nigricans in an unselected population. Am J Med 1989;87:269–72.
Little G . Meeting of the Dermatological Society of London. Br J Dermatol 1901;13:421–4.
Corrado M . Alterazioni degli annessi oculari da Acanthosis nigricans. Ann Ottalmol Clin Ocul 1940;3:161–78.
Lamba P, Lal S . Ocular changes in benign acanthosis nigricans. Dermatologica 1970;140:456–61.
Newman G, Carsten M . Acanthosis nigricans: conjunctival and lid lesions. Arch Ophthalmol 1973;90:259.
Skinner BA, Greist MC, Norins AL . The keratitis, ichthyosis and deafness (KID) syndrome. Arch Dermatol 1981;117:285–9.
Singh K . Keratitis, ichthyosis and deafness (KID syndrome). Aust J Dermatol 1987;28:38–41.
Lam S, Seabury Stone M, Goeken JA, Massicotte SJ, Smith AC, Folberg R, Krachmer JH . Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. Ophthalmology 1992;99:108–13.
Johne HO, Dengler H, Pratje A . Acanthosis nigricans with extensive skeletal changes. Arch Klin Exp Derm 1955;201:36–48.
Reddy BSN, Garg BR, Padiyar NV, Krishnaram AS . An unusual association of acanthosis nigricans and Crouzon's disease: a case report. J Dermatol 1985;12:85–90.
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Tabandeh, H., Gopal, S., Teimory, M. et al. Conjunctival involvement in malignancy-associated acanthosis nigricans. Eye 7, 648–651 (1993). https://doi.org/10.1038/eye.1993.148
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DOI: https://doi.org/10.1038/eye.1993.148