Abstract
A modular system of acquisition and analysis of Scheimpflug, retro-illumination and fluorescence images of the in vivo human crystalline lens is described. Image analysis is directed towards the following goals: Scheimpflug slit-images are analysed for: (1) The optical density of nuclear cataract present; (2) The dimensions of the lens and the lenticular zones; (3) The curvatures of the lens and lenticular zones.
Retro-illumination images are analysed for: (1) The percentage area which is occupied by cataract; (2) A combined measure (weighted integral) describing both the amount of cataract present and its optical density. Lenticular auto-fluorescence images are analysed for the mean density (fluorescence) of the lens as a whole. A pilot study of the repeatability of the methods is presented.
Similar content being viewed by others
Article PDF
References
Kahn HA, Leibowitz H, Ganley PJ, Kini M, Colton T, Nickerson R, Dawber TR : Standardizing diagnostic procedures. Am J Ophthalmol 1975-, 79: 768–75.
Sommer A : Cataracts as an epidemiologic problem. Am J Ophthalmol 1977, 83: 334–9.
Sasaki K, Oishi T, Yamaaki H, Nakamura F : Documentation of human lens by rotating photoslit-lamp. Clinical applications and examinations for the reproducibility of obtained photographs. Jpn J Ophthalmol 1979, 33: 621–7.
Leibowitz HM Krueger DE, Maunder LR et al: The Framingham eye study monograph. Survey Ophthalmol 1980, 24: (Suppl), 336–610.
Duncan G : On classifying human cataractous lenses. In: Mechanisms of cataract formation in the human lens. (1981). Ed: Duncan G. Academic Press, London. P:1–5.
Leske MC, Sperduto RD : Epidemiology of senile cataracts: A review. Am J Epidemiol 1983, 118: 152–65.
Chylack LT : Classification of human cataractous change by the American co-operative cataract research group method. In: Human cataract formation. [Ed: Nugent J, Whelan J] Pitman, London. (CIBA Foundation Symposium, 106). P: 3–24. (1984).
Sparrow JM, Ayliffe W, Bron AJ, Brown NAP, Hill AR : Inter-observer and intra-observer variability of the Oxford Clinical Cataract Classification and Grading System. Internat Ophthalmol 1988, 11: 151–7.
Brown NAP : Quantitative slit-image photography of the lens. Trans Ophthalmol Soc UK 1972, 92: 303–17.
Hockwin O, Dragomirescu V, Laser H : Measurements of lens transparency or its disturbances by densitometric image analysis of Scheimpflug photographs. Graefe's Arch Clin Exp Ophthalmol 1982, 219: 255–62.
Kawara T and Obazawa H : A new method for retroillumination photography of cataractous lens opacities. Am J Ophthalmol 1980, 90: 186–9.
Brown NAP, Bron AJ, Ayliffe W, Sparrow JM, Hill AR : the Objective Assessment of Cataract. Eye 1987, 1:234–46.
Brown NAP : The Oxford Retro-Illumination Cataract Recording Camera—a new instrument. J Audiovisual Media in Medicine 1988, 11: 58–60.
Kawara T, Obazawa H, Nakano R, Sasaki M, Sakata T : Quantatative evaluation of cataractous lens opacities with retro-illumination photography. Jpn J Ophthalmol 1979, 33: 21–6.
Maclean H, Taylor CJ : An objective staging for cortical cataract in vivo aided by pattern-analysing computer. Exp Eye Res 1981, 33: 597–602.
Chylack LT Jr, Rosner B, Cheng HM et al: Sources of variance in the objective documentation of human cataractous change with Topcon SL-45 and Neitz-CTR retroillumination photography and computerized image analysis. Curr Eye Res 1987, 6: 1381–9.
Hannah K and Tarassenko L : Tracking cataract by the four-line method. Image and Vision Computing 1989, 7: 57–62.
Wolfe JR and Chylack LT : Objective analysis of percent opacification in retro-illumination lens photographs. Invest Ophthalmol [suppl] (ARVO) 1989, 30: 328.
Shun-Shin GA, Hannah K, Bron AJ, Brown NAP : A new index of cataract progression. Invest Ophthalmol (ARVO) (Suppl) 30: 329.
Helve J and Nieminen H : Autoflouorescence of the human diabetic lens in vivo. Am J Ophthalmol 1976, 81: 491–4.
Lerman S and Hockwin O : Ultraviolet-visible slit lamp densitography of the human eye. Exp Eye Res 1981, 33: 587–96.
Shibata T and Sasaki K : Observation of Ageing Changes of Lens Transparency—Analysis of 541 eyes from Color Images. (1982) 86: 1701–8.
Sasaki K, Hiiragi M, Sakamoto Y, Shibato T : In vivo colour analysis of human crystalline lenses. Ophthalmic Res 1985, 17: 21–6.
Brown NAP : Slit-image photography. Trans Ophthalmol Soc UK 1969, 89: 397–408.
Brown NAP : An advanced slit image camera. Br J Ophthalmol 1972, 56: 624–31.
Sparrow JM : The Lens in Diabetes. D Phil Thesis, Linacre College, University of Oxford. (1988).
Brown NAP : Biometry of the lens of the eye. MD Thesis, University of Cambridge. (1975).
Shun-Shin GA, Brown NAP, Bron AJ, Sparrow JM : The dynamic nature of posterior sub-capsular cataract. Br J Ophthalmol 1989, 73: 522–7.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sparrow, J., Brown, N., Shun-Shin, G. et al. The Oxford modular cataract image analysis system. Eye 4, 638–648 (1990). https://doi.org/10.1038/eye.1990.89
Issue Date:
DOI: https://doi.org/10.1038/eye.1990.89
This article is cited by
-
Computer-aided assessment of diagnostic images for epidemiological research
BMC Medical Research Methodology (2009)
-
External factors in the development of cataract
Eye (2005)
-
Post-operative changes in the capsulorhexis aperture: A prospective, randomised comparison between loop and plate haptic silicone intraocular lenses
Eye (2000)
-
Posterior capsular opacification after cataract surgery
Eye (1999)
-
Quantitative analysis of retroillumination images
Eye (1995)