Abstract
Contrast thresholds for, and contrast matches between, stationary gratings of three spatial frequencies (0.5, 2, and 8 c/deg) were measured on eight subjects with a history of schizophrenia, just before, and again two to three days after, a therapeutic injection of depot neuroleptic. The drug enhanced sensitivity at the low, and reduced it at the medium and high spatial frequency. After injection, subjects required more contrast to match the apparent contrast of the high, and less contrast to match that of the low, to that of the medium spatial frequency. Pupillary measurements suggested that these effects were not due to drug-induced changes in pupil size. The results are discussed in terms of the functional role of dopamine in the retina, and a possible application in therapy for amblyopia.
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Frederick JM, Rayborn ME, Laties AM, Lam DMK, Hollyfield JG : Dopamine neurons in human retina. J Comp Neurol 1982, 210: 65–79.
Tork I and Turner S : Histochemical evidence for a catecholoaminergic (presumably dopaminergic) projection from the ventral tegmentum to visual cortex in the cat. Neuroscience Lett 1981, 24: 215–19.
Iuvone PM, Galli CL, Garrison-Gund CK, Neff NH : Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurones. Science 1978, 202: 901.
Iuvone PM, Galli CL, Neff NH : Retinal tyrosine hydroxylase: a comparison of short term and long term stimulation by light. Molecular Pharmacol 1978, 14: 1212.
Godley BF, Flaherty AW, Wurtman RJ : The effect of light on retinal dopamine in the rat. Ann NY Acad Sci 1985, 453: 383–4.
Thier P and Alder V : Action of iontophoretically applied dopamine on cat retinal ganglion cells. Brain Res 1984, 292: 109–21.
Jensen RJ and Daw NW : Effects of dopamine and its agonists and antagonists on the receptive field properties of ganglion cells in the rabbit retina. Neuroscience 1986, 17: 837–55.
Ehinger B : Functional role of dopamine in the retina. In: Progress in Retinal Research, Vol 2, edited by NN Osborne and GJ Chader. Pergamon Press, Oxford 1983.
Van Nes FL and Bouman MA : Variations of contrast sensitivity with luminance. J Opt Soc Am 1967, 57: 401–40.
Shapley RM and Enroth-Cugell C : Visual adaptation and retinal gain controls. Progress in Retinal Research, Vol 3, edited by NN Osborne and GJ Chader, 1984, 263–343.
Bodis-Wollner I : Altered spatio-temporal contrast vision in Parkinson's disease and MPTP-treated monkeys: the role of dopamine. In: Dopaminergic mechanisms in vision. Eds: I Bodis-Wollner and M Piccolino. New York: AR Liss, Inc., 1988, pp 205–20.
Bodis-Wollner I, Yahr MD, Thornton JA : Visual evoked potentials and the severity of Parkinson's disease. In: Research Progress in Parkinson's Disease. Eds: FC Rose and R Capildeo, Tunbridge Wells: Pitman Medical, 1981.
Ellis CJK and Ikeda H : Evidence for retinal dopamine deficiency in Parkinson's disease. In: Dopaminergic mechanisms in vision. Eds: I Bodis-Wollner and M Piccolino. New York: AR Liss, Inc., 1988, pp 239–51.
Domenici L, Trimarchi C, Piccolino M, Fiorentini A, Maffei L : Dopaminergic drugs improve visual contrast sensitivity. Hum Neurobiol 1985, 4: 195–7.
Harris JP and Calvert JE : Contrast, spatial frequency and test duration effects on the tilt aftereffect: Implications for underlying mechanisms. Vis Res 1989, 29: 129–35.
Calvert JE, Harris JP, Phillipson OT : Effects of L-dopa on the tilt aftereffect with differing stimulus contrast and test duration. Clin Vis Sci 1990, 5: 87–90.
Calvert JE, Harris JP, Phillipson OT : Probing the visual system of Parkinson's disease and chronic schizophrenic patients on depot neuroleptic using the tilt aftereffect. (In preparation.)
Harris JP, Low I, Makepeace APW : A programmable waveform generator to produce stationary and moving gratings for visual research. J Physiol 1982, 327: 15P.
Mariani AP, Kolb H, Nelson R : Dopamine-containing cells of the rhesus monkey retina parallel rods in spatial distribution. Brain Res 1984, 322: 1–7.
Nguyen-Legros J and Savy C : Dopamine innervation of the vertebrate retina: Morphological studies. In: Dopaminergic mechanisms in vision. Eds: I Bodis-Wollner and M Piccolino. New York: AR Liss Inc., 1988, pp 1–17.
Beaumont SM, Harris JP, Leendertz JA, Phillipson OT : The pupillary light reflex in mild Parkinson's disease. Clin Vis Sci 1987, 2: 123–9.
Jorgensen A, Hansen V, Larsen VD, Khan AR : Metabolism, distribution and excretion of flupenthixol. Acta Pharmacol Toxicol 1969, 27: 301–13.
Barlow HB, Fitzhugh R, Kuffler SW : Change of organisation in the receptive fields of the cat's retina during dark adaptation. J Physiol 1957, 137: 338–54.
Gottlob I and Stangler-Zuschrott E : Effect of levodopa on contrast sensitivity and scotomas in human amblyopia. Invest Ophthalmol Vis Sci 1990, 31: 776–80.
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Harris, J., Calvert, J., Leendertz, J. et al. The influence of dopamine on spatial vision. Eye 4, 806–812 (1990). https://doi.org/10.1038/eye.1990.127
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DOI: https://doi.org/10.1038/eye.1990.127
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