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Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action

An Erratum to this article was published on 01 December 2007

Abstract

Lipoprotein plays a role in the host defense against bacterial infection, and its serum level has been demonstrated to be an important prognosis factor of survival. We have previously demonstrated that LDL directly inactivates the hemolytic activity of Vibrio vulnificus cytolysin (VVC) in vitro. The object of this study was therefore to examine whether the LDL-mediated inactivation of VVC leads to protection against lethal infection of V. vulnificus in vivo, using wild and VVC-deficient V. vulnificus strains. Unexpectedly, we found that LDL protects mouse lethality induced by VVC-deficient as well as wild V. vulnificus strain. We also demonstrated that LDL blocks V. vulnificus LPS-induced lethality in mice. These results suggest that LDL preferentially act on endotoxin rather than exotoxin in the protection against V. vulnificus-induced mice lethality.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, KH., Kim, JS., Lee, YR. et al. Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action. Exp Mol Med 39, 673–678 (2007). https://doi.org/10.1038/emm.2007.73

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Keywords

  • endotoxemia
  • lipopolysaccharides
  • lipoproteins
  • LDL
  • Vibrio vulnificus
  • vvP protein
  • Vibrio vulnificus

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