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Clinical nutrition

Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial

European Journal of Clinical Nutrition volume 72, pages 99–104 (2018)Cite this article

Subjects

Abstract

Background/Objectives:

Pemphigus vulgaris (PV), as an autoimmune disease including mucosa and the skin, is associated with several complications and comorbidities. The present study planned to determine the effect of L-carnitine (LC) supplementation on biomarkers of oxidative stress (OS), antioxidant capacity and lipid profile in PV patients.

Subjects/Methods

Fifty two control and patients with PV, participated in the current randomized, double-blind, placebo-controlled clinical trial. The patients were allocated randomly to receive 2 g per day LC tartrate subdivided into two equal doses of 1 g before breakfast and dinner (n=26) or placebo (n=26) for 8 weeks. Anthropometric, lipid profile and OS values were determined at baseline and end of intervention period.

Results:

LC intake significantly reduced serum levels of triglycerides, total-, LDL- cholesterol and oxidative stress index (OSI; P<0.05). In addition, supplementation with LC resulted to a meaningful increase in levels of total antioxidant capacity (TAC) (P=0.05) and serum carnitine (P<0.001). LC intake revealed non-significant change in serum total oxidant capacity (P=0.15) and HDL- cholesterol (P=0.06) in comparison to the placebo.

Conclusions:

LC consumption may have favorable results on TAC, OSI and lipid profiles in patients with PV. The results were in line with the idea that LC supplementation can be associated with positive effects on metabolic status and OS of patients with PV.

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Acknowledgements

This work is a part of MSc thesis supported by by the grants from TUMS (No.28824). We are thankful to all patients who contributed dedicatedly in the study.

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Authors and Affiliations

  1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    H Mohammadi, M Djalali, N M Honarvar, F Sepandar, Z Fakhri, E Yaghubi, M Zarei & M H Javanbakht

  2. Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

    M Daneshpazhooh & C Chams‐Davatchi

Authors
  1. H Mohammadi
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  2. M Djalali
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  3. M Daneshpazhooh
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  6. F Sepandar
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Correspondence to M H Javanbakht.

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Mohammadi, H., Djalali, M., Daneshpazhooh, M. et al. Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 72, 99–104 (2018). https://doi.org/10.1038/ejcn.2017.131

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