Epidemiology

Alcohol consumption and the risk for renal hyperfiltration in the general Chinese population

Subjects

Abstract

Background/Objectives:

Glomerular hyperfiltration has been considered an early marker of kidney injury in prediabetes and prehypertension. Heavy alcohol consumption remains highly prevalent and is considered a major public health problem worldwide. The degree of glomerular hyperfiltration associated with alcohol consumption remains unclear.

Subjects/Methods:

This study was conducted in three communities in China. A total of 15 390 participants (5396 males and 9994 females) aged 40–65 years were included in the study. Glomerular hyperfiltration was defined as estimated glomerular filtration rate >97.5th percentile value of the total population.

Results:

Current drinkers had a 1.51 times higher risk for developing renal hyperfiltration (RHF) as compared with never drinkers, adjusted for age, body mass index, smoking status, systolic and diastolic blood pressure, physical activity and the levels of fasting glucose, triglyceride, total cholesterol, low-density lipoprotein and high-density lipoprotein. Furthermore, heavy alcohol consumption of >210 g per week was associated with an elevated risk for RHF in a dose-dependent manner among male current drinkers.

Conclusions:

In middle-aged Chinese men, heavy alcohol intake was associated with an elevated risk for RHF. On the other hand, former drinkers or light–moderate alcohol intake did not show any increased risks for these conditions.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Ronksley z, Brien SE, Turner BJ, Mukamal KJ, Ghali WA . Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 2011; 342: d671.

  2. 2

    Knott C, Bell S, Britton A . Alcohol consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of more than 1.9 million individuals from 38 observational studies. Diabetes Care 2015; 38: 1804–1812.

  3. 3

    Baliunas DO, Taylor BJ, Irving H, Roerecke M, Patra J, Mohapatra S et al. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2009; 32: 2123–2132.

  4. 4

    Schrieks IC, Heil AL, Hendriks HF, Mukamal KJ, Beulens JW . The effect of alcohol consumption on insulin sensitivity and glycemic status: a systematic review and meta-analysis of intervention studies. Diabetes Care 2015; 38: 723–732.

  5. 5

    Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G . Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med 2006; 166: 2437–2445.

  6. 6

    Rehm J, Gmel G, Sempos CT, Trevisan M . Alcohol-related morbidity and mortality. Alcohol Res Health 2003; 27: 39–51.

  7. 7

    Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2224–2260.

  8. 8

    Smyth A, Teo KK, Rangarajan S, O'Donnell M, Zhang X, Rana P et al. Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study. Lancet 2015; 386: 1945–1954.

  9. 9

    Knott CS, Coombs N, Stamatakis E, Biddulph JP . All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts. BMJ 2015; 350: h384.

  10. 10

    Ruggenenti P, Porrini EL, Gaspari F, Motterlini N, Cannata A . Carrara F, et al. Glomerular hyperfiltration and renal disease progression in type 2 diabetes. Diabetes Care 2012; 35: 2061–2068.

  11. 11

    Moriya T, Tsuchiya A, Okizaki S, Hayashi A, Tanaka K, Shichiri M . Glomerular hyperfiltration and increased glomerular filtration surface are associated with renal function decline in normo- and microalbuminuric type 2 diabetes. Kidney Int 2012; 81: 486–493.

  12. 12

    Palatini P, Mormino P, Dorigatti F, Santonastaso M, Mos L, De Toni R et al. Glomerular hyperfiltration predicts the development of microalbuminuria in stage 1 hypertension: the HARVEST. Kidney Int 2006; 70: 578–584.

  13. 13

    Wuerzner G, Pruijm M, Maillard M, Bovet P, Renaud C, Burnier M et al. Marked association between obesity and glomerular hyperfiltration: a cross-sectional study in an African population. Am J Kidney Dis 2010; 56: 303–312.

  14. 14

    Park M, Yoon E, Lim YH, Kim H, Choi J, Yoon HJ . Renal hyperfiltration as a novel marker of all-cause mortality. J Am Soc Nephrol 2015; 26: 1426–1433.

  15. 15

    Maeda I, Hayashi T, Sato KK, Koh H, Harita N, Nakamura Y et al. Cigarette smoking and the association with glomerular hyperfiltration and proteinuria in healthy middle-aged men. Clin J Am Soc Nephrol 2011; 6: 2462–2469.

  16. 16

    Melsom T, Mathisen UD, Eilertsen BA, Ingebretsen OC, Jenssen T, Njolstad I et al. Physical exercise, fasting glucose, and renal hyperfiltration in the general population: the Renal Iohexol Clearance Survey in Tromso 6 (RENIS-T6). Clin J Am Soc Nephrol 2012; 7: 1801–1810.

  17. 17

    Huang C, Guo C, Nichols C, Chen S, Martorell R . Elevated levels of protein in urine in adulthood after exposure to the Chinese famine of 1959-61 during gestation and the early postnatal period. Int J Epidemiol 2014; 43: 1806–1814.

  18. 18

    Koning SH, Gansevoort RT, Mukamal KJ, Rimm EB, Bakker SJ, Joosten MM . Alcohol consumption is inversely associated with the risk of developing chronic kidney disease. Kidney Int 2015; 87: 1009–1016.

  19. 19

    Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K . Alcohol and coronary heart disease: a meta-analysis. Addiction 2000; 95: 1505–1523.

  20. 20

    Standards of medical care in diabetes–2015: summary of revisions. Diabetes Care 2015; 38 (Suppl), S4.

  21. 21

    James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014; 311: 507–520.

  22. 22

    Chen G, Chen L, Wen J, Yao J, Li L, Lin L et al. Associations between sleep duration, daytime nap duration, and osteoporosis vary by sex, menopause, and sleep quality. J Clin Endocrinol Metab 2014; 99: 2869–2877.

  23. 23

    Melsom T, Mathisen UD, Ingebretsen OC, Jenssen TG, Njolstad I, Solbu MD et al. Impaired fasting glucose is associated with renal hyperfiltration in the general population. Diabetes Care 2011; 34: 1546–1551.

  24. 24

    Schaeffner ES, Kurth T, de Jong PE, Glynn RJ, Buring JE, Gaziano JM . Alcohol consumption and the risk of renal dysfunction in apparently healthy men. Arch Intern Med 2005; 165: 1048–1053.

  25. 25

    Yamagata K, Ishida K, Sairenchi T, Takahashi H, Ohba S, Shiigai T et al. Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study. Kidney Int 2007; 71: 159–166.

  26. 26

    Shankar A, Klein R, Klein BE . The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol 2006; 164: 263–271.

  27. 27

    White SL, Polkinghorne KR, Cass A, Shaw JE, Atkins RC, Chadban SJ . Alcohol consumption and 5-year onset of chronic kidney disease: the AusDiab study. Nephrol Dial Transplant 2009; 24: 2464–2472.

  28. 28

    Roerecke M, Rehm J . Alcohol consumption, drinking patterns, and ischemic heart disease: a narrative review of meta-analyses and a systematic review and meta-analysis of the impact of heavy drinking occasions on risk for moderate drinkers. BMC Med 2014; 12: 182.

  29. 29

    Fukushima W, Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y et al. Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan. BMC Neurol 2010; 10: 111.

  30. 30

    Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L, Grzeszczak W et al. Glomerular hyperfiltration: a new marker of metabolic risk. Kidney Int 2007; 71: 816–821.

  31. 31

    Husain K, Ansari RA, Ferder L . Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol 2014; 6: 245–252.

  32. 32

    Albano E . Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 2006; 65: 278–290.

  33. 33

    Feunekes GI, van 't Veer P, van Staveren WA, Kok FJ . Alcohol intake assessment: the sober facts. Am J Epidemiol 1999; 150: 105–112.

Download references

Acknowledgements

This study was supported by grants from the Chinese Medical Association Foundation and Chinese Endocrine Society (12020240314), National Natural Science Foundation of China (81270874, 81570706, 81200538), Natural Science Foundation of Fujian Province (2011J06012, 2014J05083), Provincial Health and Family Planning Commission of Fujian Province (2013-ZQN-ZD-3), National Clinical Research Center for Metabolic Diseases (2013BAI09B13) and the National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology (2012ZX09303006-001).

Author information

Correspondence to G Chen.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark