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Maternal and pediatric nutrition

Multicausal etiology of anemia among women of reproductive age in Vietnam

European Journal of Clinical Nutrition volume 69, pages 107–113 (2015)Cite this article

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Abstract

Background/Objectives:

Anemia is a significant public health concern, especially among women and young children. An improved understanding of the complex etiology of anemia is crucial for developing appropriate prevention strategies. This paper examines the determinants of anemia in a large sample of Vietnamese women of reproductive age (WRA).

Methods:

We included baseline data from 4986 WRA participating in a randomized controlled trial (PRECONCEPT). Hemoglobin (Hb) concentrations were measured with Hemocue. Plasma ferritin (Fe), retinol binding protein (RBP) and markers of inflammation were assessed using the ELISA technique. We used multivariate logistic regression to describe associations with anemia and structural equation modeling (SEM) to characterize direct and indirect pathways influencing Hb concentrations.

Results:

Prevalence of anemia, iron deficiency (Fe <12 μg/l), insufficient iron stores (Fe<30 μg/l) and iron deficiency anemia was 19.7, 3.5, 14.4 and 1.9%, respectively. Ferritin concentration (0.29 per log-mg/dl), being an ethnic minority (−0.24 compared with Kinh), number of children (−0.17) and socioeconomic status (0.09) were directly associated with Hb concentration (P<0.05). Similarly, RBP was directly (0.27 per mg/dl) associated with Hb and also indirectly (0.09 mg/dl) with ferritin. Hookworm infection was indirectly associated with Hb (−0.11) through RBP and ferritin.

Conclusion:

These findings illustrate the complex etiology of anemia and provide a useful framework for designing, targeting and evaluating appropriate strategies for the prevention and control of anemia. Contrary to expectations, iron deficiency accounted for a very small proportion of anemia in Northern Vietnam.

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Acknowledgements

Funding for this research was provided by the Mathile Institute for the Advancement of Human Nutrition and the Micronutrient Initiative.

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Authors and Affiliations

  1. Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam

    P H Nguyen, H Nguyen, H Pham, T V Truong & S Nguyen

  2. and Nutrition Division, Poverty, Health, International Food Policy Research Institute, Hanoi, Vietnam

    P H Nguyen

  3. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

    I Gonzalez-Casanova, R Martorell & U Ramakrishnan

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Nguyen, P., Gonzalez-Casanova, I., Nguyen, H. et al. Multicausal etiology of anemia among women of reproductive age in Vietnam. Eur J Clin Nutr 69, 107–113 (2015). https://doi.org/10.1038/ejcn.2014.181

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