Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Consumption of rapeseed honey leads to higher serum fructose levels compared with analogue glucose/fructose solutions

Abstract

Background:

Studies suggest that honey has less influence on serum glucose concentrations than monosaccharides and disaccharides. Previous studies, however, have only analysed glucose metabolism.

Methods:

This study investigated the influence of two types of honey (rapeseed and acacia) on the serum levels of glucose, fructose, insulin and C-peptide values in healthy subjects. The results were compared with honey-comparable glucose–fructose solutions. All solutions contained 75 g of glucose and/or fructose.

Results:

We found significantly higher fructose serum levels with rapeseed honey after 2 h but no such differences for acacia honey. C-peptide levels were significantly higher after administration of both honeys after 1 and 2 h.

Conclusions:

For the first time it has been found out that honey ingestion leads to a rise of blood fructose concentration: in one case, this rise was lower than that achieved after fructose/glucose controls, in the other cases it was same as after the controls. Fructose metabolism may be inhibited by unidentified substances present in the rapeseed honey. Further study to elucidate underlying mechanisms may be worthwhile, as usually there is no differentiation between the different types of honey.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  • Agrawal OP, Pachauri A, Yadav H, Urmila J, Goswamy HM, Chapperwal A et al. (2007). Subjects with impaired glucose tolerance exhibit a high degree of tolerance to honey. J Med Food 10, 473–478.

    Article  CAS  Google Scholar 

  • Ahmad A, Azim MK, Mesaik MA, Khan RA (2008). Natural honey modulates physiological glycemic response compared to simulated honey and D-glucose. J Food Sci 73, H165–H167.

    Article  CAS  Google Scholar 

  • Al-Waili NS (2004). Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. J Med Food 7, 100–107.

    Article  CAS  Google Scholar 

  • American Diabetes Association (2006). Standards of medical care in diabetes—2006. Diabetes Care 29 (Suppl 1), S4–S42.

    Google Scholar 

  • Bornet F, Haardt MJ, Costagliola D, Blayo A, Slama G (1985). Sucrose or honey at breakfast have no additional acute hyperglycaemic effect over an isoglucidic amount of bread in type 2 diabetic patients. Diabetologia 28, 213–217.

    Article  CAS  Google Scholar 

  • Katsilambros NL, Philippides P, Touliatou A, Georgakopoulos K, Kofotzouli L, Frangaki D et al. (1988). Metabolic effects of honey (alone or combined with other foods) in type II diabetics. Acta Diabetol Lat 25, 197–203.

    Article  CAS  Google Scholar 

  • Münstedt K, Bargello M, Hauenschild A (2009a). Royal jelly and its influence on serum fructose and serum lipids. J ApiProduct ApiMedical Sci 1, 90–91.

    Article  Google Scholar 

  • Münstedt K, Hoffmann S, Hauenschild A, Bülte M, von Georgi R, Hackethal A (2009b). Effect of honey on serum cholesterol and lipid values. J Med Food 12, 624–628.

    Article  Google Scholar 

  • Münstedt K, Sheybani B, Hauenschild A, Brüggmann D, Bretzel RG, Winter D (2008). Effects of basswood honey, honey-comparable glucose-fructose solution, and oral glucose tolerance test solution on serum insulin, glucose, and C-peptide concentrations in healthy subjects. J Med Food 11, 424–428.

    Article  Google Scholar 

  • Oizumi T, Daimon M, Jimbu Y, Kameda W, Arawaka N, Yamaguchi H et al. (2007). A palatinose-based balanced formula improves glucose tolerance, serum free fatty acid levels and body fat composition. Tohoku J Exp Med 212, 91–99.

    Article  CAS  Google Scholar 

  • Schaefer EJ, Gleason JA, Dansinger ML (2009). Dietary fructose and glucose differentially affect lipid and glucose homeostasis. J Nutr 139, 1257S–1262S.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank the volunteers for their assistance and acknowledge the support of a grant from Stiftung Dr Abel–Apis mellifica, Germany.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K Münstedt.

Ethics declarations

Competing interests

The authors no declare conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Münstedt, K., Böhme, M., Hauenschild, A. et al. Consumption of rapeseed honey leads to higher serum fructose levels compared with analogue glucose/fructose solutions. Eur J Clin Nutr 65, 77–80 (2011). https://doi.org/10.1038/ejcn.2010.186

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2010.186

Keywords

This article is cited by

Search

Quick links