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The effects of psyllium on lipoproteins in type II diabetic patients

Abstract

We examined the effects of 2 months of psyllium treatment in optimizing metabolic control and lipoprotein profile, and its postprandial effects on lipids in type II diabetes. We recruited 40 type II diabetic patients who were on sulfonylureas and a controlled diet, sequentially assigning them to psyllium treatment (G1) or to a control group (G2) treated with dietary measures alone. After 2 months of treatment, body mass index, waist circumference, HbA1c (hemoglobin A1c) and fasting plasma glucose levels had significantly decreased in both groups. There were no postprandial differences in the lipoprotein profile between the two groups. Triglycerides were significantly lower in G1, but not in G2. Our study contributes toward elucidating the effects of psyllium on serum lipids, and suggests that psyllium treatment may help in reducing triglycerides (a known risk factor for cardiovascular disease) in type II diabetic patients.

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References

  • Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA et al. (2000). Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 71, 472–479.

    Article  CAS  PubMed  Google Scholar 

  • Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN et al. (2006). Effects of breakfast meal composition on second meal metabolic responses in adults with type 2 diabetes mellitus. Eur J Clin Nutr 60, 1122–1129.

    Article  CAS  PubMed  Google Scholar 

  • Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499–502.

    CAS  PubMed  Google Scholar 

  • Jarjis HA, Blackburn NA, Redfern JS, Read NW (1984). The effect of ispaghula (Fybogel and Metamucil) and guar gum on glucose tolerance in man. Br J Nutr 51, 371–378.

    Article  CAS  PubMed  Google Scholar 

  • Jaynes PK, Willis MC, Chou PP (1985). Evaluation of a mini-column chromatographic procedure for the measurement of haemoglobin A1c. Clin Biochem 18, 32–36.

    Article  CAS  PubMed  Google Scholar 

  • Lipid Research Clinics Program (1982). Lipid and lipoprotein analyses. Hainline A, Karon J, Lippel K (eds). In: Manual of Laboratory Operations, 2nd edn, US Department of Health and Human Service: Washington, DC. pp 63–77.

  • Neal GW, Balm TK (1990). Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia. S Med J 83, 1131–1137.

    Article  CAS  Google Scholar 

  • Rodriguez-Moran M, Guerrero-Romero F, Lazcano-Burciaga GJ (1998). Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes. J Diabetes Complications 12, 273–278.

    Article  CAS  PubMed  Google Scholar 

  • Sierra M, Garcia JJ, Fernandez N, Diez MJ, Calle AP, Farmafibra Group (2002). Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 56, 830–842.

    Article  CAS  PubMed  Google Scholar 

  • Van Rosendaal GMA, Shaffer EA, Alun LE, Brant R (2004). Effect of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or slightly hypercholesterolemic subjects. Nutr J 28, 3–17.

    Google Scholar 

  • Wahlefeld AW (1976). Triglycerides determination after enzymatic hydrolysis. In: Bergmeyer HU (ed). Methods of Enzymatic Analyses. Academic Press: New York. pp 1831–1835.

    Google Scholar 

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Correspondence to G Sartore.

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Sartore, G., Reitano, R., Barison, A. et al. The effects of psyllium on lipoproteins in type II diabetic patients. Eur J Clin Nutr 63, 1269–1271 (2009). https://doi.org/10.1038/ejcn.2009.60

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  • DOI: https://doi.org/10.1038/ejcn.2009.60

Keywords

  • type 2 diabetes
  • lipoproteins
  • psyllium
  • dietary fiber

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