Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • RESEARCH HIGHLIGHT

Testing the genome-editing toolkit in cardiomyopathy

  1. Katie Kingwell
    View author publications

    You can also search for this author in PubMed  Google Scholar

Genome editing has progressed rapidly from discovery to clinical development, while preclinical studies continue to refine the approaches. Now, two papers in Nature Medicine showcase the potential of two such strategies — base editing and CRISPR–Cas9 — for prevention of hypertrophic cardiomyopathy (HCM) in mouse models. The studies also highlight different advantages and challenges for each genome-editing strategy.

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature Reviews Drug Discovery 22, 270 (2023)

doi: https://doi.org/10.1038/d41573-023-00046-4

References

  1. Chai, A. C. et al. Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice. Nat. Med. 29, 401–411 (2023)

    PubMed  Google Scholar 

  2. Reichart, D. et al. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nat. Med. 29, 412–421 (2023)

    PubMed  Google Scholar 

Download references

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links