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  • RESEARCH HIGHLIGHT

MYC inhibition, courtesy of E. coli

  1. Karen O'Leary
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The MYC oncogene is upregulated in many cancers, and this upregulation is associated with a negative prognosis, but efforts to target MYC have been unsuccessful. Butler and Cafaro et al. have identified a novel mechanism of MYC inhibition by uropathogenic Escherichia coli, which may have therapeutic potential.

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Nature Reviews Drug Discovery 20, 264 (2021)

doi: https://doi.org/10.1038/d41573-021-00039-1

This article originally appeared in Nat. Rev. Cancer (https://doi.org/10.1038/s41568-021-00345-1)

References

  1. Butler, D. S. C. et al. A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer. Nat. Biotechnol. https://doi.org/10.1038/s41587-020-00805-3 (2021)

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