Degrading sialoglycans delays tumour growth

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Cell surface sialoglycans suppress immune activation and are upregulated in malignancy, representing a potential target for cancer immune therapy. Building on previous work, Gray et al. optimize a targeted degradation strategy, in which a sialic acid-cleaving enzyme (sialidase) is fused to a HER2-targeting antibody, trastuzumab, to catalytically degrade sialoglycans in a tumour-specific manner. In mouse breast cancer models, the antibody–sialidase conjugate delayed tumour growth and enhanced immune cell infiltration, prolonging survival. These effects were dependent on Siglec-E checkpoint receptor expression on tumour-infiltrating myeloid cells.

Nature Reviews Drug Discovery 19, 672 (2020)


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    Gray, M. A. et al. Targeted glycan degradation potentiates the anticancer immune response in vivo. Nat. Chem. Biol. (2020)

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