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Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Potassium channels are the largest group of ion channels, and various diseases caused by mutations in genes encoding these channels have been identified. One such sodium-activated potassium channel includes KNa1.1 subunits, encoded by KCNT1. Gain-of-function mutations are associated with drug-resistant, early-onset epileptic encephalopathies, and so KNa1.1 channels could be a promising therapeutic target.
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Nature Reviews Drug Discovery19, 502 (2020)
doi: https://doi.org/10.1038/d41573-020-00092-2
Acknowledgements
This article is part of a series from the NIH Common Fund Illuminating the Druggable Genome (IDG) programme. The goal of IDG is to catalyse research on understudied proteins from druggable gene families by providing reagents, phenotypes and a mineable database; focusing on GPCRs, kinases and ion channels. This work is funded by NIH grant 1U24DK116214-01. For more information, see https://druggablegenome.net/