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Innate immunity in tuberculosis: host defense vs pathogen evasion

Cellular & Molecular Immunology volume 14, pages 963–975 (2017)Cite this article

Abstract

The major innate immune cell types involved in tuberculosis (TB) infection are macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune cells recognize the TB-causing pathogen Mycobacterium tuberculosis (Mtb) through various pattern recognition receptors (PRRs), including but not limited to Toll-like receptors (TLRs), Nod-like receptors (NLRs) and C-type lectin receptors (CLRs). Upon infection by Mtb, the host orchestrates multiple signaling cascades via the PRRs to launch a variety of innate immune defense functions such as phagocytosis, autophagy, apoptosis and inflammasome activation. In contrast, Mtb utilizes numerous exquisite strategies to evade or circumvent host innate immunity. Here we discuss recent research on major host innate immune cells, PRR signaling, and the cellular functions involved in Mtb infection, with a specific focus on the host’s innate immune defense and Mtb immune evasion. A better understanding of the molecular mechanisms underlying host–pathogen interactions could provide a rational basis for the development of effective anti-TB therapeutics.

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Acknowledgements

We acknowledge research funding from the National Key Research and Development Program of China (Grant Nos. 2017YFA0505900 and 2017YFD0500300), the National Basic Research Programs of China (Grant No. 2014CB74440), the National Natural Science Foundation of China (Grant Nos. 81371769 and 81571954), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDPB03) and the Youth Innovation Promotion Association CAS (Grant No. Y12A027BB2).

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  1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China

    Cui Hua Liu

  2. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 101408, China

    Cui Hua Liu

  3. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China

    Haiying Liu

  4. Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China

    Baoxue Ge

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Liu, C., Liu, H. & Ge, B. Innate immunity in tuberculosis: host defense vs pathogen evasion. Cell Mol Immunol 14, 963–975 (2017). https://doi.org/10.1038/cmi.2017.88

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