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Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1α response

Cellular & Molecular Immunology volume 7, pages 355–360 (2010)Cite this article

Abstract

Chemokines and their receptors are important mediators of leukocyte trafficking and recruitment and sometimes work as modulators of T-cell responses during infections and inflammation. Modulating the biological activity of chemokines has been found to influence the course of diseases. However, little is known about the role of chemokine responses during chlamydial lung infections. We therefore analyzed the dynamics of multiple chemokines, which are frequently associated with type 1 (Th1) T cell immune responses, and their receptors for their expression in the lungs during Chlamydia muridarum (Cm) infections. We also examined the relationship between chemokine responses and the development of Th1 responses as well as the clearance of infection. Our results showed that in parallel with the high levels of gamma interferon (IFN-γ) and IL-12 production in the lungs and draining lymph nodes, and the expansion of IFN-γ-producing CD4 and CD8+ T cells, the production of the cell-related chemokines RANTES, IFN-γ-inducible protein-10 (IP-10) and macrophage inflammatory protein-1α (MIP-1α) and their receptor CCR1 was elevated in the lung tissues after infection. Interestingly, in a later phase of infection, the expression of RANTES and IP-10 remained elevated but the expression of MIP-1α and CCR1 decreased to a low level, which suggests a closer association with the pattern of Th1 cytokine responses in the process of infection. These results suggest a close association between the MIP-1α response and the Th1-type T-cell responses in chlamydial lung infections.

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Acknowledgements

This work was supported by a fund from the Tianjin Municipal Science and Technology Commission (07JCYBJC10600).

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Author notes

  1. Naihong Zhang and Zhaoe Wang: These authors contributed equally to this work.

  2. Dr X Yang, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Room 523, 730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada. E-mail: yangxi@cc.umanitoba.ca

  3. Dr H Bai, Department of Immunology, Tianjin Medical University, 22 Qixiangtai Road, Heping Distinct, Tianjin 300070, China.E-mail: hongbai25@163.com

Authors and Affiliations

  1. Department of Immunology, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin, China

    Naihong Zhang, Zhaoe Wang, Xiaofei Tang, Haiping Wang, Hongzhao Li, Huanjun Huang, Hong Bai & Xi Yang

  2. Departments of Medical Microbiology and Immunology, Laboratory for Infection and Immunity, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

    Xi Yang

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  1. Naihong Zhang
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Zhang, N., Wang, Z., Tang, X. et al. Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1α response. Cell Mol Immunol 7, 355–360 (2010). https://doi.org/10.1038/cmi.2010.32

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