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Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice

Cellular & Molecular Immunology volume 6, pages 67–72 (2009)Cite this article

Abstract

Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis, M. vaccae was injected into Mycobacterium tuberculosis (M. tuberculosis) infected mice. The optimal dose of M. vaccae (22.5 µg/mouse) treated mice showed lower pathological change index, spleen weight index, lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells, IFN-γ+CD4+ T cells, innate immune cells including NK cells, NK1.1+ T cells and γδ T cells, and reduced the percentage of IL-4+CD4+ T cells. Therefore, M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity, suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis.

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Authors and Affiliations

  1. Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China

    Lijun Xu

  2. Institute of Immunology, School of Life Sciences, University of Science & Technology of China, Hefei, 230027, Anhui, China

    Yanyan Wang, Xiaodong Zheng & Haiming Wei

  3. Anhui Longcome Biological Pharmacy Co. Ltd, Hefei, 230088, Anhui, China

    Xiangdong Gui & Lifeng Tao

Authors
  1. Lijun Xu
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  2. Yanyan Wang
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  3. Xiaodong Zheng
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  4. Xiangdong Gui
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  5. Lifeng Tao
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  6. Haiming Wei
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Correspondence to Lijun Xu or Haiming Wei.

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Xu, L., Wang, Y., Zheng, X. et al. Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice. Cell Mol Immunol 6, 67–72 (2009). https://doi.org/10.1038/cmi.2009.9

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  • DOI: https://doi.org/10.1038/cmi.2009.9

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