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Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells

Cellular & Molecular Immunology volume 7, pages 51–60 (2010)Cite this article

Abstract

The chemokine thymus-expressed chemokine (TECK), which regulates T-cell development and tissue-specific homing, has been identified as a potential contributor to the pathogenesis and progression of endometriosis. Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), an air pollutant, and estrogen also appear to be involved in endometriosis. Both endometrial stromal cells (ESCs) and the combination of 17β-estradiol and TCDD increase the secretion of TECK in the endometriosis-associated cells and promote the invasiveness of ESCs by increasing expression of matrix metalloproteinase (MMP)-2 and MMP-9. Anti-TECK neutralizing antibodies can effectively inhibit the invasiveness of ESCs and the expression of MMP-2 and MMP-9 in the cells. Interestingly, the expression of chemokine C receptor 9 (CCR9) and its ligand TECK increases significantly in the endometriotic milieu of patients with endometriosis. Therefore, the over-expressed TECK interacts with CCR9 on the ESCs in the endometriotic milieu, which may contribute to the onset and progression of endometriosis.

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Acknowledgements

This work was supported by the National Basic Research Program of China (2006CB944007, to DJ Li), the National and Shanghai Leading Academic Discipline Project (211XK22, to DJ Li) and the Program for Outstanding Medical Academic Leader of Shanghai (to DJ Li). The human peritoneal mesothelial cell line (HMrSV5) was generously provided by Professor Jian Yao (The First People’s Hospital, Shanghai, China)

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  1. Dr D J Li, Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai 200011, China. E-mail: djli@shmu.edu.cn

Authors and Affiliations

  1. Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai 200011, China

    Yun Wang, Jing Yu, Xuezhen Luo, Xiaoqiu Wang, Mingqing Li, Ling Wang & Dajin Li

  2. Department of Obstetrics and Gynecology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China

    Dajin Li

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Wang, Y., Yu, J., Luo, X. et al. Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. Cell Mol Immunol 7, 51–60 (2010). https://doi.org/10.1038/cmi.2009.102

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