Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice

Cellular & Molecular Immunology volume 6, pages 73–77 (2009)Cite this article

Abstract

Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, 050017, China

    Cuiqing Ma, Caihong Li, Xiurong Wang, Ruihong Zeng, Xiaolin Yin, Huidong Feng & Lin Wei

Authors
  1. Cuiqing Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Caihong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiurong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ruihong Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaolin Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Huidong Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lin Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lin Wei.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ma, C., Li, C., Wang, X. et al. Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice. Cell Mol Immunol 6, 73–77 (2009). https://doi.org/10.1038/cmi.2009.10

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/cmi.2009.10

Keywords

Search

Advanced search

Quick links