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The Expression of CD2 in Chronic HBV Infection

Cellular & Molecular Immunology volume 5, pages 69–73 (2008)Cite this article

Abstract

It was previously reported that several kinds of intercellular adhesion molecules are closely related to chronic HBV infection. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. In this study, we detected the level of CD2 expressed on the surface of PBMC, the expression level of CD2 mRNA in PBMC and the percentage of CD2 positive cells in PBMC of patients with chronic HBV infection and compared them with the expression level of normal controls. We also determined the level of serum HBV DNA from patients with chronic HBV infection and from normal controls. The clinical characteristics of hepatic function were tested as well. The results showed that the expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection.

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Authors and Affiliations

  1. Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an, 710061, China

    Jie Li, Baotai Qi, Ping Chen, Linjing He, Ping Wang, Yuqiang Ji & Ming Xie

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  1. Jie Li
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  2. Baotai Qi
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  3. Ping Chen
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  4. Linjing He
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  5. Ping Wang
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  6. Yuqiang Ji
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  7. Ming Xie
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Correspondence to Ming Xie.

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Li, J., Qi, B., Chen, P. et al. The Expression of CD2 in Chronic HBV Infection. Cell Mol Immunol 5, 69–73 (2008). https://doi.org/10.1038/cmi.2008.9

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  • DOI: https://doi.org/10.1038/cmi.2008.9

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