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Pretransplant vaccinations in allogeneic stem cell transplantation donors and recipients: an often-missed opportunity for immunoprotection?

Bone Marrow Transplantation volume 50, pages 899–903 (2015)Cite this article

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Abstract

Immune deficiency following hematopoietic cell transplantation predisposes the patient to potentially deadly infections. Vaccinations can improve immunity and thus reduce the morbidity and mortality associated with these infections. Over the years different sets of guidelines have been published the most recent by the Infectious Diseases Society of American (IDSA). There is limited evidence that vaccination of donors and/or recipients before transplantation may improve immunity. However, despite the possibility of augmented immunity, there remain logistical, ethical and medical concerns about such a vaccination strategy.

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Acknowledgements

Hava Fife, ACNP; Melissa Logue, ACNP (Blood and Marrow Transplant Nurse Practitioner, Vanderbilt University Medical Center, Nashville, TN, USA)

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Authors and Affiliations

  1. Section of Hematology and Stem Cell Transplantation, Vanderbilt University Medical Center, Nashville, TN, USA

    A E Harris & B N Savani

  2. Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

    J Styczynski

  3. Department of Pharmacy, Veterans Affairs Medical Center, Nashville, TN, USA

    M Bodge

  4. Department of Haematology, Saint Antoine Hospital, Paris, France

    M Mohty

  5. INSERM UMR 938, Paris, France

    M Mohty

  6. Université Pierre et Marie Curie, Paris, France

    M Mohty

  7. Departments of Hematology and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden

    P Ljungman

  8. Division of Hematology, Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden

    P Ljungman

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  1. A E Harris
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Correspondence to B N Savani.

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Harris, A., Styczynski, J., Bodge, M. et al. Pretransplant vaccinations in allogeneic stem cell transplantation donors and recipients: an often-missed opportunity for immunoprotection?. Bone Marrow Transplant 50, 899–903 (2015). https://doi.org/10.1038/bmt.2015.49

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  • DOI: https://doi.org/10.1038/bmt.2015.49

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