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Inflammatory bowel disease after allogeneic stem cell transplantation

Bone Marrow Transplantation volume 50, pages 1365–1366 (2015)Cite this article

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Gastrointestinal (GI) disorders frequently occur after allogeneic stem cell transplantation (allo-SCT), infections and GvHD represent the most frequent events. They develop as a consequence of tissue damage, particularly in the GI tract, induced by the conditioning regimen. Release of damage-associated molecular pattern molecules and pathogen-associated molecular pattern molecules after conditioning induces the activation of the innate and adaptive immune responses leading to GI GvHD. Despite sharing common pathophysiology pathways with GI GvHD, inflammatory bowel disease (IBD) has been occasionally described after allo-SCT.

We report here a case of IBD occurring 1 year after allo-SCT in the context of post-transplant immune dysfunction.

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Acknowledgements

We thank the nursing staff for providing excellent care for our patients, the transplant coordination nurses and the following physicians: P Coppo, JP Marie, R Dulery, NC Gorin, AL Ruggeri, M Aoudjhane, L Garderet, F Isnard, MP Lemonnier, E Corre, A Gomez, S Lapusan, O Legrand, AC Mamez, E Brissot, A Vekhoff, Z Marjanovic, R Adaeva, H Benredouane, M Labopin and R Belhocine for their dedicated patient care. IB was supported by educational grants from the ‘Association for Training, Education and Research in Hematology, Immunology and Transplantation’ (ATERHIT). Our group is supported by several grants from the French National Cancer Institute (PHRC, INCa to MM).

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Authors and Affiliations

  1. Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

    I Boussen, M Mohty & M T Rubio

  2. Université Pierre et Marie Curie, UPMC Univ Paris 06, Paris, France

    I Boussen, H Sokol, O Georges, N Hoyeau-Idrissi, M Mohty & M T Rubio

  3. Service de Gastroentérologie et Nutrition, Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France

    H Sokol

  4. Service de Dermatologie, Hôpital Cochin, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France

    S Aractingi

  5. Université Paris Descartes, Univ Paris 05, Paris, France

    S Aractingi

  6. Laboratoire d’Anatomo-Cyto-Pathologie, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

    O Georges

  7. Laboratoire d’Anatomo-Cyto-Pathologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

    N Hoyeau-Idrissi

  8. Service des maladies digestives et respiratoires de l’enfant, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

    J P Hugot

  9. Centre de recherche sur l’inflammation, UMR 1149, Inserm - Université Paris Diderot, Univ Paris 07, Paris, France

    J P Hugot

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  1. I Boussen
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  2. H Sokol
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  7. M Mohty
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  8. M T Rubio
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Corresponding author

Correspondence to M T Rubio.

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Boussen, I., Sokol, H., Aractingi, S. et al. Inflammatory bowel disease after allogeneic stem cell transplantation. Bone Marrow Transplant 50, 1365–1366 (2015). https://doi.org/10.1038/bmt.2015.138

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