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Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor

Bone Marrow Transplantation volume 47, pages 1587–1588 (2012)Cite this article

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Auto-SCT has been established as an effective treatment for patients with hematological malignancies such as lymphoma or myeloma. Unfortunately, some patients fail to mobilize a sufficient number of PBSCs for transplantation. Plerixafor is the first molecule to reversibly inhibit the binding of chemokine stromal cell-derived factor-1α (SDF-1α) to its cognate receptor, CXCR4.1 Many recent reports have shown that there is a potential clinical application for plerixafor in PBSC harvesting.2, 3, 4, 5, 6

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal component and Skin changes) syndrome is a rare paraneoplastic syndrome secondary to plasma cell dyscrasia. As this disease is rare, no standard treatment has been developed. However, treatment options for this syndrome, such as the use of thalidomide, lenalidomide, bortezomib and bevacizumab (an antivascular endothelial growth factor (VEGF) Ab), have increased in the past decade. To date, high-dose melphalan followed by auto-SCT has been demonstrated to be the most effective treatment strategy.7, 8 However, patients with poor mobilization cannot undergo auto-SCT. In addition, PBSC harvesting in patients with this syndrome is challenging, and these patients are at a higher risk than those with other hematological malignancies, because of poor performance status, morbidities associated with uncontrollable effusions and splenomegaly.7 Here, we report two poorly mobilized cases of POEMS syndrome in which PBSCs were successfully harvested using G-CSF with plerixafor.

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Authors and Affiliations

  1. Department of Hematology, Chiba University Hospital, Chiba, Japan

    N Shimizu, E Sakaida, C Ohwada, M Takeuchi, T Kawaguchi, S Tsukamoto, S Sakai, Y Takeda, Y Sugita & C Nakaseko

  2. Department of Blood Transfusion, Chiba University Hospital, Chiba, Japan

    N Shimizu & T Iseki

  3. Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan

    K Yokote

  4. Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan

    S Isose, K Kanai, S Misawa & S Kuwabara

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  1. N Shimizu
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Correspondence to C Nakaseko.

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Shimizu, N., Sakaida, E., Ohwada, C. et al. Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor. Bone Marrow Transplant 47, 1587–1588 (2012). https://doi.org/10.1038/bmt.2012.80

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