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Hepatic GVHD leading to cirrhosis after allogeneic hematopoietic SCT

Bone Marrow Transplantation volume 47, pages 1484–1485 (2012)Cite this article

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Graft-versus-host-disease (GVHD) is a major complication after allogeneic hematopoietic SCT (alloHSCT). Although GVHD of the liver is not known as a fibrogenic process, we recently observed two cases of cirrhosis attributed to the evolution of hepatic GVHD.

Both patients received an alloHSCT after reduced-intensity conditioning regimen, for an advanced hematological malignancy (Table 1). The source of stem cells was peripheral blood and GVHD prophylaxis was CsA and mycophenolate mofetil. Before the alloHSCT, none of the patients had any history of hepatic failure; liver function tests (LFTs) were within the normal range and viral hepatitis serologies were negative for both donors and recipients.

Table 1 Patients′ characteristics
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Figure 1

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Authors and Affiliations

  1. Hématologie-greffe, hôpital Saint-Louis, APHP, Paris, France

    A Xhaard, M Robin, R Peffault de Latour & G Socié

  2. Hépato-gastro-entérologie, hôpital Jean Verdier, Bondy, France

    P Nahon

  3. Hépato-gastro-entérologie, hôpital Saint-Louis, APHP, Paris, France

    C Baudry

  4. Hématologie clinique, Hôpital Avicenne, APHP, Bobigny, France

    L Ades

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  1. A Xhaard
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  2. P Nahon
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  3. M Robin
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  4. C Baudry
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  6. R Peffault de Latour
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  7. G Socié
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Correspondence to A Xhaard.

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Xhaard, A., Nahon, P., Robin, M. et al. Hepatic GVHD leading to cirrhosis after allogeneic hematopoietic SCT. Bone Marrow Transplant 47, 1484–1485 (2012). https://doi.org/10.1038/bmt.2012.53

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