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Azacitidine in the treatment of extramedullary relapse of AML after allogeneic hematopoietic cell transplantation

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  1. Bekassy AN, Hermans J, Gorin NC, Gratwohl A . Granulocytic sarcoma after allogeneic bone marrow transplantation: a retrospective European multicenter survey. Acute and Chronic Leukemia Working Parties of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 1996; 17: 801–808.

    CAS  PubMed  Google Scholar 

  2. Berthou C, Leglise MC, Herry A, Balcon D, Hardy E, Lessard M et al. Extramedullary relapse after favorable molecular response to donor leukocyte infusions for recurring acute leukemia. Leukemia 1998; 12: 1676–1681.

    Article  CAS  PubMed  Google Scholar 

  3. Cunningham I . Extramedullary sites of leukemia relapse after transplant. Leuk Lymphoma 2006; 47: 1754–1767.

    Article  PubMed  Google Scholar 

  4. Frassoni F, Barrett AJ, Granena A, Ernst P, Garthon G, Kolb HJ et al. Relapse after allogeneic bone marrow transplantation for acute leukaemia: a survey by the E.B.M.T. of 117 cases. Br J Haematol 1988; 70: 317–320.

    Article  CAS  PubMed  Google Scholar 

  5. Koc Y, Miller KB, Schenkein DP, Daoust P, Sprague K, Berkman E . Extramedullary tumors of myeloid blasts in adults as a pattern of relapse following allogeneic bone marrow transplantation. Cancer 1999; 85: 608–615.

    Article  CAS  PubMed  Google Scholar 

  6. Lee KH, Lee JH, Choi SJ, Kim S, Seol M, Lee YS et al. Bone marrow vs extramedullary relapse of acute leukemia after allogeneic hematopoietic cell transplantation: risk factors and clinical course. Bone Marrow Transplant 2003; 32: 835–842.

    Article  CAS  PubMed  Google Scholar 

  7. Savani BN, Mielke S, Reddy N, Goodman S, Jagasia M, Rezvani K . Management of relapse after allo-SCT for AML and the role of second transplantation. Bone Marrow Transplant 2009; 44: 769–777.

    Article  CAS  PubMed  Google Scholar 

  8. de Lima M, Giralt S, Thall PF, de Padua Silva L, Jones RB, Komanduri K et al. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study. Cancer 2010; 116: 5420–5431.

    Article  CAS  PubMed  Google Scholar 

  9. Platzbecker U, Wermke M, Radke J, Oelschlaegel U, Seltmann F, Kiani A et al. Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial. Leukemia 2012; 26: 381–389.

    Article  CAS  PubMed  Google Scholar 

  10. Serrao A, Loglisci G, Salaroli A, Zacheo I, Alimena G, Breccia M . Azacitidine followed by radiotherapy as effective treatment for chronic myelomonocytic leukemia with extramedullary localization. Leuk Lymphoma, (e-pub ahead of print 9 July 2012).

    Article  Google Scholar 

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Correspondence to A Bazarbachi.

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Antar, A., Otrock, Z., Kharfan-Dabaja, M. et al. Azacitidine in the treatment of extramedullary relapse of AML after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 48, 994–995 (2013). https://doi.org/10.1038/bmt.2012.256

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