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Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians

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Abstract

The Pretransplantation Assessment of Mortality (PAM) score is a risk score for mortality after allogeneic hematopoietic SCT (HSCT). Ethnicity is a genetically determined factor that correlated with immune-mediated outcomes of allogeneic HSCT. We evaluated the predictive value of the PAM score for transplant outcome in 276 Japanese populations in which transplant-related complications occur less frequently than Caucasians. The PAM score effectively risk-stratified these patients for survival; overall survival (OS) at 2 years was 100%, 80.2%, 49.4%, and 13.9% in the categories 1, 2, 3, and 4, respectively, showing a clear distinction of OS by categories (P<0.001). In addition, the PAM score is useful for the prediction of transplant outcomes both in patients with standard-risk underlying diseases and those with high-risk diseases. The PAM score developed in Caucasian populations is thus useful in non-Caucasian populations.

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Acknowledgements

This work was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports and Science and Technology in Japan to TT.

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Correspondence to T Teshima.

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The authors declare no conflict of interest.

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Mori, Y., Teshima, T., Kamezaki, K. et al. Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians. Bone Marrow Transplant 47, 1075–1081 (2012) doi:10.1038/bmt.2011.229

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Keywords

  • PAM score
  • hematopoietic SCT
  • prognosis
  • Japanese

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