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Antiviral treatment of Influenza A (H1N1-09) guided by molecular resistance testing in aplasia after allo-SCT

Bone Marrow Transplantation volume 46, pages 1492–1494 (2011)Cite this article

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Pulmonary injury is a major cause of morbidity and mortality in patients after SCT. Although bacterial and fungal infections account for most infections, a variety of viruses can be involved as well. In the SCT setting, particularly during aplasia, early after transplantation, patients are most vulnerable and therefore urgently need effective anti-infection drugs. We report the clinical course and molecular data of a patient who acquired influenza A (H1N1-09) pneumonia in aplasia after SCT.

We present the case of a 59-year-old woman with kappa light-chain myeloma, who was transplanted in second CR. Previous treatment comprised high-dose melphalan and autologous hematopoietic cell transplantation, and salvage therapy with bortezomib and dexamethasone.

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References

  1. Casper C, Englund J, Boeckh M . How I treat influenza in patients with hematologic malignancies. Blood 2010; 115: 1331–1342.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. WHO. Update on oseltamivir-resistant pandemic A (H1N1) 2009 influenza virus: January 2010. Wkly Epidemiol Rec 2009; 85: 37–40.

    Google Scholar 

  3. Gubareva LV, Kaiser L, Matrosovich MN, Soo-Hoo Y, Hayden FG . Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J Infect Dis 2001; 183: 523–531.

    Article  CAS  PubMed  Google Scholar 

  4. Ives JAL, Carr JA, Mendel DB, Tai CY, Lambkin R, Kelly L et al. The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. Antiviral Res 2002; 55: 307–317.

    Article  CAS  PubMed  Google Scholar 

  5. Hayden FG . Combination antiviral therapy for respiratory virus infections. Antiviral Res 1996; 29: 45–48.

    Article  CAS  PubMed  Google Scholar 

  6. Nguyen JT, Hoopes JD, Le MH, Smee DF, Patick AK, Faix DJ et al. Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PLoS ONE 2010; 5: e9332.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Gubareva LV, Matrosovich MN, Brenner MK, Bethell RC, Webster RG . Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus. J Infect Dis 1998; 178: 1257–1262.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Uniklinikum Dresden, MK1, Dresden, Germany

    N Shayegi, M Bornhäuser, G Ehninger & J Schetelig

  2. RKI (Nationales Referenzzentrum für Influenza), Robert Koch-Institut, Berlin, Germany

    B Schweiger & S Duwe

  3. Uniklinikum Dresden, Institut für medizinische Mikrobiologie und Hygiene, Dresden, Germany

    C Pöhlmann

Authors
  1. N Shayegi
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  2. B Schweiger
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  3. S Duwe
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  4. C Pöhlmann
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  5. M Bornhäuser
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  6. G Ehninger
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  7. J Schetelig
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Correspondence to N Shayegi.

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Shayegi, N., Schweiger, B., Duwe, S. et al. Antiviral treatment of Influenza A (H1N1-09) guided by molecular resistance testing in aplasia after allo-SCT. Bone Marrow Transplant 46, 1492–1494 (2011). https://doi.org/10.1038/bmt.2010.331

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