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Atypical presentation of progressive multifocal leukoencephalopathy in a multiple myeloma patient after auto-SCT successfully treated with combination therapy

Bone Marrow Transplantation volume 45, pages 1668–1670 (2010)Cite this article

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We read with interest the article by Kharfan-Dabaja et al.1 on two cases of fatal progressive multifocal leukoencephalopathy (PML) that developed after SCT. We report on a patient who developed this type of complication after autologous SCT.

Lumbar puncture was performed, and evaluation of the cerebrospinal fluid was negative for malignant cells and for infection, showing only protein level to be mildly elevated (48 mg/dl).

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References

  1. Kharfan-Dabaja MA, Ayala E, Greene J, Rojiani A, Murtagh FR, Anasetti C . Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. Bone Marrow Transplant 2007; 39: 101–107.

    Article  CAS  Google Scholar 

  2. Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego-Mendoza MM, Allaire N, Simon K et al. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother 2009; 53: 1840–1849.

    Article  CAS  Google Scholar 

  3. Koralnik IJ . New insights into progressive multifocal leukoencephalopathy. Curr Opin Neurol 2004; 17: 365–370.

    Article  Google Scholar 

  4. Carson KR, Evens AM, Richey EA, Habermann TM, Focosi D, Seymour JF et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood 2009; 113: 4834–4840.

    Article  CAS  Google Scholar 

  5. Blick G, Whiteside M, Griegor P, Hopkins U, Garton T, LaGravinese L . Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside. Clin Infect Dis 1998; 26: 191–192.

    Article  CAS  Google Scholar 

  6. Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 2004; 306: 1380e3.

    Article  Google Scholar 

  7. Rodriguez M, Lennon VA . Immunoglobulins promote remyelination in the central nervous system. Ann Neurol 1990; 27: 12–17.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto di Ematologia, Università Cattolica Sacro Cuore, Rome, Italy

    L Fianchi, M T Voso, G Leone & L Pagano

  2. Istituto di Radiologia, Università Cattolica Sacro Cuore, Rome, Italy

    C Colosimo

  3. Istituto di Malattie Infettive, Università Cattolica Sacro Cuore, Rome, Italy

    A De Luca

  4. Dipartimento di Neurochirurgia, Università Cattolica Sacro Cuore, Rome, Italy

    A Pompucci

  5. Istituto di Microbiologia, Università Cattolica Sacro Cuore, Rome, Italy

    P Cattani

  6. Istituto di Anatomia Patologica, Università Cattolica Sacro Cuore, Rome, Italy

    L M LaRocca

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  1. L Fianchi
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  2. C Colosimo
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  3. A De Luca
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  8. G Leone
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  9. L Pagano
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Correspondence to L Fianchi.

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Fianchi, L., Colosimo, C., De Luca, A. et al. Atypical presentation of progressive multifocal leukoencephalopathy in a multiple myeloma patient after auto-SCT successfully treated with combination therapy. Bone Marrow Transplant 45, 1668–1670 (2010). https://doi.org/10.1038/bmt.2010.33

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