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Conditioning Regimens

BU- vs TBI-based conditioning for adult patients with ALL

Bone Marrow Transplantation volume 46, pages 1413–1417 (2011)Cite this article

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Abstract

Evidence suggests an advantage for TBI over BU as a component of conditioning regimens for allogeneic hematopoietic cell transplant in patients with ALL. We have employed both TBI and BU for conditioning in ALL and reviewed our experience to compare outcomes. From July 1989 to June 2008, we identified 86-adult ALL patients treated with either a TBI- or BU-based regimen and transplanted with either a well-matched sibling or unrelated donor. Data including demographics, immunophenotype, disease status and cytogenetic risk were examined by Cox proportional hazards analysis. Patients treated with TBI were older (median age 40 vs 33 years; P=0.018), had a higher-risk cytogenetic profile (P=0.010), were more often transplanted using an unrelated donor (P=0.038) and were treated more recently (P<0.001). There was a significant improvement in EFS (P=0.046), and a trend to improved OS (P=0.08) in patients treated with TBI compared with those treated with BU. However, the advantage for TBI could not be confirmed by multivariable analysis where only disease status retained statistical significance.

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Authors and Affiliations

  1. Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

    M Kalaycio, B Bolwell, S Andresen, B Pohlman, R Dean, R Sobecks & E Copelan

  2. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    L Rybicki

  3. Hematology–BMT, Princess Norah Oncology Center, King Khaled Hospital, Jeddah, Saudi Arabia

    A Absi

Authors
  1. M Kalaycio
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  2. B Bolwell
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  3. L Rybicki
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  4. A Absi
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  6. B Pohlman
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  7. R Dean
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  8. R Sobecks
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Correspondence to M Kalaycio.

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Competing interests

Dr Sobecks receives research support from Otsuka America Pharmaceutical Inc. The other authors declare no conflict of interest.

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Kalaycio, M., Bolwell, B., Rybicki, L. et al. BU- vs TBI-based conditioning for adult patients with ALL. Bone Marrow Transplant 46, 1413–1417 (2011). https://doi.org/10.1038/bmt.2010.314

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  • DOI: https://doi.org/10.1038/bmt.2010.314

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