Abstract
Since the beginning of hematopoietic stem cell harvesting from volunteer unrelated donors, ensuring donor safety has been a necessary goal of all parties involved in the process. As donation of BM or PBSCs is not in the interest of the donor's own physical health, donor registries and transplantation centers must take into account both medical and ethical aspects involved in the donation procedure. One of the principal goals leading to the formation of the World Marrow Donor Association (WMDA) was to establish internationally acceptable standards for all aspects of unrelated donor care.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Goldman JM . A special report: bone marrow transplants using volunteer donors—recommendations and requirements for a standardized practice throughout the world—1994 update. The WMDA Executive Committee. Blood 1994; 84: 2833–2839.
Bakken R, van Walraven AM, Egeland T . Donor commitment and patient needs. Bone Marrow Transplant 2004; 33: 225–230.
Rosenmayr A, Hartwell L, Egeland T . Informed consent—suggested procedures for informed consent for unrelated haematopoietic stem cell donors at various stages of recruitment, donor evaluation, and donor workup. Bone Marrow Transplant 2003; 31: 539–545.
Duffy M, Coffey K . Confidentiality donor—patient. http://www.worldmarrow.org/fileadmin/WorkingGroups_Subcommittees/EWG/Confidentiality_EWG_2008.pdf. Accessed on 13 January 2010.
http://www.jacie.org/portal/jacie/standards. Accessed on 13 January 2010.
Sacchi N, Costeas P, Hartwell L, Hurley CK, Raffoux C, Rosenmayr A et al. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant 2008; 42: 9–14.
Egeland T, Lie J, Persson U, Raymond J, Muller C . Donor and liability insurance of donor registries, donor centers, and collection centers—recommendations. Bone Marrow Transplant 2004; 33: 467–470.
Heard P, Hartwell L, Greinix H . Patient consent to donor terms and transplant centre expectations. http://www.worldmarrow.org. Accessed on 13 January 2010.
BSBMT. http://www.bsbmt.org/pages/64-Indications_Table, Accessed on 13 January 2010.
Ljungman P, Bregni M, Brune M, Cornelissen J, Witte TD, Dini G et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (e-pub ahead of print 6 July 2009).
Ljungman P, Urbano-Ispizua A, Cavazzana-Calvo M, Demirer T, Dini G, Einsele H et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 2006; 37: 439–449.
Subsequent donations, clinical working group, link to projects. http://www.worldmarrow.org. Accessed on 13 January 2010.
Cell dose survey response, clinical working group, link to projects. http://www.worldmarrow.org. Accessed on 13 January 2010.
Bennett CL, Evens AM, Andritsos LA, Balasubramanian L, Mai M, Fisher MJ et al. Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project. Br J Haematol 2006; 135: 642–650.
Confer DL, Miller JP . Long-term safety of filgrastim (rhG-CSF) administration. Br J Haematol 2007; 137: 77–78; author reply 79–80.
Goldman JM, Madrigal JA, Pamphilon D . Possible harmful effects of short course granulocyte colony-stimulating factor in normal donors. Br J Haematol 2006; 135: 651–652.
McCullough J, Kahn J, Adamson J, Anderlini P, Benjamin R, Confer D et al. Hematopoietic growth factors—use in normal blood and stem cell donors: clinical and ethical issues. Transfusion 2008; 48: 2008–2025.
Nagler A, Korenstein-Ilan A, Amiel A, Avivi L . Granulocyte colony-stimulating factor generates epigenetic and genetic alterations in lymphocytes of normal volunteer donors of stem cells. Exp Hematol 2004; 32: 122–130.
Pamphilon D, Nacheva E, Navarrete C, Madrigal A, Goldman J . The use of granulocyte-colony-stimulating factor in volunteer unrelated hemopoietic stem cell donors. Transfusion 2008; 48: 1495–1501.
Tulpule S, Shaw BE, Makoni P, Little AM, Madrigal JA, Goldman JM . Severe allergic reaction with anaphylaxis to G-CSF (lenograstim) in a healthy donor. Bone Marrow Transplant 2009; 44: 129–130.
Wanner M, Bochert S, Schreyer IM, Rall G, Rutt C, Schmidt AH . Losing the genetic twin: donor grief after unsuccessful unrelated stem cell transplantation. BMC Health Serv Res 2009; 9: 2.
World Marrow Donor Association (WMDA) Guidelines for couriers and the transportation of haemopoietic progenitor cells (HPC-BM, apheresis and therapeutic cells- T Cells). http://www.worldmarrow.org/fileadmin/WorkingGroups_Subcommittees/DRWG/WMDA_Courier_and_Transportation_Guidelines.pdf. Accessed on 13 January 2010.
Halter J, Kodera Y, Ispizua AU, Greinix HT, Schmitz N, Favre G et al. Severe events in donors after allogeneic hematopoietic stem cell donation. Haematologica 2009; 94: 94–101.
Holig K, Kramer M, Kroschinsky F, Bornhauser M, Mengling T, Schmidt AH et al. Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3928 donors. Blood 2009; 114: 3757–3763.
Pulsipher MA, Chitphakdithai P, Miller JP, Logan BR, King RJ, Rizzo JD et al. Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program. Blood 2009; 113: 3604–3611.
Acknowledgements
We thank Carolyn Hurley, Effie Petersdorf, Lydia Foeken, Jeremy Chapman and members of the WMDA board for critical reading of the paper.
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Shaw, B., Ball, L., Beksac, M. et al. Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerations. Bone Marrow Transplant 45, 832–838 (2010). https://doi.org/10.1038/bmt.2010.2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/bmt.2010.2
Keywords
This article is cited by
-
Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors
International Journal of Hematology (2023)
-
Donor assessment and follow-up: not a minor issue
Bone Marrow Transplantation (2019)
-
Audits of collection and apheresis centers: guidelines by the World Marrow Donor Association Working Group Quality and Regulation
Bone Marrow Transplantation (2019)
-
GMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration
Stem Cell Research & Therapy (2017)
-
The impact of improved JACIE standards on the care of related BM and PBSC donors
Bone Marrow Transplantation (2015)