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Successful bone marrow transplantation in a girl with Fanconi anemia and preterminal renal failure

Bone Marrow Transplantation volume 42, pages 57–58 (2008)Cite this article

Fanconi anemia is a hereditary disorder characterized by congenital defects, including urogenital anomalies, progressive bone marrow failure and a high incidence of cancer. Allogeneic BMT is the therapy of choice for Fanconi patients with progressive pancytopenia. Because most conditioning regimens contain potentially nephrotoxic agents, BMT in Fanconi patients with both hematological and renal problems is a challenging procedure.

We describe a girl with Fanconi anemia and chronic renal failure who was successfully transplanted from an HLA-identical sibling after an adjusted conditioning regimen consisting of fludarabine and thoracoabdominal irradiation.

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Authors and Affiliations

  1. Department of Pediatric Hematology/Oncology, UMCU/Wilhelmina Children's Hospital, Utrecht, The Netherlands

    K M J Heitink-Pollé & M B Bierings

  2. Department of Pediatric Nephrology, UMCU/Wilhelmina Children's Hospital, Utrecht, The Netherlands

    M R Lilien

Authors
  1. K M J Heitink-Pollé
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  2. M R Lilien
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  3. M B Bierings
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Correspondence to K M J Heitink-Pollé.

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Heitink-Pollé, K., Lilien, M. & Bierings, M. Successful bone marrow transplantation in a girl with Fanconi anemia and preterminal renal failure. Bone Marrow Transplant 42, 57–58 (2008). https://doi.org/10.1038/bmt.2008.43

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