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Stem Cell Collection

Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study

Bone Marrow Transplantation volume 43, pages 357–363 (2009)Cite this article

Abstract

Mobilized allogeneic PBPC are increasingly used instead of BM for allogeneic stem cell grafting. Although the short-term safety profile of recombinant human (rh)G-CSF seems acceptable, only minimal data on long-term safety are available. We therefore reviewed data on 171 sibling donors (M/F: 98/73) with respect to side effects of rhG-CSF and PBPC collection and impact on quality of life (QoL) and health status. In a cross-sectional study, we investigated the actual QoL and health status of the donors as well as the need for medical treatment since PBPC donation by a questionnaire that was sent to 151 donors. Ninety-five (64%) of the addressed donors responded to the questionnaire, but only 69 (46%) of them reported on their actual health status and QoL, which was good to very good in the majority of them. Two donors developed malignancies in the post-donation course. In general, PBPC collection after rhG-CSF mobilization was well tolerated by the responding donors. Although the reported events in medical history after PBPC donation do not seem to be associated with rhG-CSF administration or the collection procedure, a lifelong follow-up of donors should be obligatory.

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Authors and Affiliations

  1. Department of Transfusion Medicine, Medical University of Vienna, Vienna, Austria

    G C Leitner, K Baumgartner, P Hoecker & N Worel

  2. Department of Internal Medicine I, Bone Marrow Transplantation, Medical University of Vienna, Vienna, Austria

    P Kalhs, D Biener & H T Greinix

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  1. G C Leitner
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  2. K Baumgartner
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  3. P Kalhs
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Correspondence to G C Leitner.

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Leitner, G., Baumgartner, K., Kalhs, P. et al. Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study. Bone Marrow Transplant 43, 357–363 (2009). https://doi.org/10.1038/bmt.2008.335

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