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Post-Transplant Events

Frequency of human metapneumovirus infection in hematopoietic SCT recipients during 3 consecutive years

Bone Marrow Transplantation volume 42, pages 265–269 (2008)Cite this article

Abstract

Respiratory viruses can cause significant morbidity in immunocompromised hosts. Human metapneumovirus (hMPV) has been increasingly associated with lower respiratory tract infection in hematopoietic SCT (HSCT) recipients, with mortality rates up to 50%. No data on the occurrence of hMPV infection in HSCT recipients have been reported in the southern hemisphere. We conducted a retrospective study including 228 nasal wash samples from 153 HSCT recipients with respiratory symptoms during 2001, 2002 and 2003. hMPV was detected by real-time PCR with primers complementary to the nucleocapsid region of hMPV genome. Eleven of the 153 patients (7.2%) acquired hMPV infection during the study period (6.4% in 2001, 4.7% in 2002 and 11.1% in 2003). Among the 11 HSCT recipients with hMPV infection, 1 died 8 days after the diagnosis, but the role of hMPV in the patient's death could not be established. In 2001 and 2003, hMPV group A prevailed over group B. In 2002, both groups were detected equally. hMPV infections were diagnosed in late winter and spring. The frequency of hMPV infection in HSCT recipients living in Brazil was similar to those observed in the northern hemisphere. Sensitive techniques to detect hMPV should be included in the diagnostic assessment of HSCT recipients with respiratory symptoms.

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Acknowledgements

This study was supported by FAPESP Grant no. 05/01455-5. We thank Dr Frederico L Dulley and the clinicians assisting the HSCT recipients for excellent health care; Dr Tereza Peret (Center for Diseases Control, USA), Dr Edson Durigon (Instituto de Ciências Biomédicas, USP, Brazil) and Dr Vivian Luchsinger (Programa de Virología, University of Chile) for suggestions and technical support.

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Authors and Affiliations

  1. Virology Laboratory, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil

    R R Oliveira, A F Machado, A F Tateno, LS Vilas Boas, C S Pannuti & C M Machado

  2. Departamento de Moléstias Infecciosas e Parasitárias, University of São Paulo Medical School, São Paulo, Brazil

    C S Pannuti

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  1. R R Oliveira
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  2. A F Machado
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  3. A F Tateno
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  4. LS Vilas Boas
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  5. C S Pannuti
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  6. C M Machado
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Correspondence to C M Machado.

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Oliveira, R., Machado, A., Tateno, A. et al. Frequency of human metapneumovirus infection in hematopoietic SCT recipients during 3 consecutive years. Bone Marrow Transplant 42, 265–269 (2008). https://doi.org/10.1038/bmt.2008.153

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